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157286-86-7

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157286-86-7 Usage

Uses

A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

Biological Activity

Selective, non-peptide CRF 1 receptor antagonist (K i values are 2.7 and > 10000 nM for CRF 1 and CRF 2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (K i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

Check Digit Verification of cas no

The CAS Registry Mumber 157286-86-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,2,8 and 6 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 157286-86:
(8*1)+(7*5)+(6*7)+(5*2)+(4*8)+(3*6)+(2*8)+(1*6)=167
167 % 10 = 7
So 157286-86-7 is a valid CAS Registry Number.

157286-86-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine

1.2 Other means of identification

Product number -
Other names CP 154,526

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:157286-86-7 SDS

157286-86-7Downstream Products

157286-86-7Relevant articles and documents

Pyrrolopyrimidines as CRF antagonists

-

, (2008/06/13)

The compounds of the formula wherein R1, R2, R3, R4, R5and R6are as defined herein, are useful in the treatment of stress-related and other diseases. These compounds have corticotropin-releasing factor antagonist activity and as such are of use in the treatment of stress and anxiety related, and other disorders.

QT dispersion and heart rate variability improvement with CRF antagonists to prevent sudden death

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, (2008/06/13)

A method of preventing sudden death which comprises administering to a mammal, including a human, a therapeutically effective amount of a corticotropin releasing factor antagonist.

PYRAZOLOPYRIMIDINES FOR TREATMENT OF CNS DISORDERS

-

, (2008/06/13)

This invention relates to the use of pyrazolopyrimidines and pyrrolopyrimidine of, respectively, the general formula STR1 wherein A, X, R 3, R 4 and R 5 are as defined below, and the pharmaceutically acceptable salts of such compounds, to treat, prevent or inhibit certain neuronal and other disorders.

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