157287-10-0Relevant academic research and scientific papers
N-acyl aziridines - C-acylating agents for the preparation of polyketides
Lygo, Barry
, p. 5073 - 5074 (1994)
A one-pot synthesis of N-acylaziridines from carboxylic acids has been developed, and their reaction with dianions derived from β-ketoesters studied. The aziridines were found to be efficient C-acylating agents, giving polyketide-like products in good ove
HYDROXY SUBSTITUTED 1H-IMIDAZOPYRIDINES AND METHODS
-
Page/Page column 48-49, (2010/11/26)
Hydroxy substituted 1H-imidazo[4,5-c]pyridin-4-amines, with a hydroxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
N-Acyl-2-methylaziridines: Synthesis and utility in the C-acylation of β-ketoester derived dianions
Lygo, Barry
, p. 12859 - 12868 (2007/10/02)
A 'one pot' method for the preparation of N-acyl-2-methylaziridines is described, and the utility of these compounds in the C-acylation of dianions derived from β-ketoesters investigated. Application of the methodology to the synthesis of the polyketide natural product yangonin is also described.
