1639970-62-9

Basic information

• Product Name: (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid
• Synonyms: (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid;LCZ703;LCZ-696 Impurity 16
• CAS NO: 1639970-62-9
• Molecular Formula: C22H23NO4
• Molecular Weight: 365.42232
• Product Categories: LCZ696
• Mol File: 1639970-62-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid(1639970-62-9)
• EPA Substance Registry System: (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid(1639970-62-9)

Safety Data

• Hazardous Substances Data: 1639970-62-9(Hazardous Substances Data)

Usage

General Description

(2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid is a complex organic compound with a specific stereochemistry and a long chemical name. It contains a biphenyl group, a methyl group, and a pyrrolidin-1-yl group, attached to a 2-methyl-4-butanoic acid backbone. (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid may have potential applications in medicinal chemistry, given its structural features and the presence of functional groups that could potentially be targeted for drug development. However, it would require further studies to determine its specific biological activities and potential uses.

Upstream product

• 1012341-50-2 (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 
• 752174-62-2 (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester 
• 1038924-97-8 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrol-1-yl)-2-methyl pentanoate 
• 1573000-28-8 (S)-1-([1,1’-biphenyl]-4-yl)-3-chloropropan-2-ol 
• 1573000-36-8 (1-([1,1‘-biphenyl]-4-yl)-3-chloropropan-2-yl)pyrrolidine-2,5-dione 
• 92-66-0 4-bromo-1,1'-biphenyl 

Relevant articles and documents

Preparation method of

The preparation method comprises the following steps 1-11: Wherein. ROH (Formula X) is a chiral alcohol and the like, PG is a hydroxy protecting group, a compound of Formula VI and a compound of Formula V are the chiral auxiliary of the present invention. To the invention, the chiral auxiliary base ROH compound and the chiral alcohol X (Formula VI) are used for preparing the chiral auxiliary base-type compound of formula V IV and the compound of Formula XI, and the compound of formula IV can be prepared through three-step simple operation steps of chiral auxiliary base. Be applicable to industrial production.

Sacubitril intermediate and preparation method and application thereof

The invention discloses a sacubitril intermediate and a preparation method and application thereof. The sacubitril intermediate has the chemical structure as shown in the formula III and/or formula IV, wherein R is phenyl, benzyl and isopropyl. The application of the intermediate for synthesis of sacubitril has advantages as follows: the preparation process is simple; the reaction condition is mild; and the environment is protected. The invention has great significance and use value for low-cost, large-sale and high-efficiency preparation of high-purity sacubitril.

A LCZ696 preparation method of drug impurity (by machine translation)

The present invention provides a LCZ696 preparation method of drug impurities, including: the (2 R, 4 S) - 5 - (biphenyl - 4 - yl) - 4 - [(uncle butoxy carbonyl) amino] - 2 - methyl valeric acid in chloro- medicinal preparation in the reaction with the organic alcohol, in order to get the product and succinic anhydride as a raw material, preparation (2 R, 4 S) - 5 - biphenyl - 4 - yl - 4 - (2, 5 - dicarbonyl - pyrrolidine - 1 - yl) - 2 - methyl pentanoate; make (2 R, 4 S) - 5 - biphenyl - 4 - yl - 4 - (2, 5 - dicarbonyl - pyrrolidine - 1 - yl) - 2 - methyl pentanoate hydrolyzed under acidic conditions, make (2 R, 4 S) - 5 - biphenyl - 4 - yl - 4 - (2, 5 - dicarbonyl - pyrrolidine - 1 - yl) - 2 - methyl valeric acid. The method of the invention the operation is simple, low cost, and is capable of LCZ696 pharmaceutical quality control to provide qualified reference substance. (by machine translation)