1574-87-4

Basic information

• Product Name: 4-(4-methoxyphenyl)-5-nitropentan-2-one
• CAS NO: 1574-87-4
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.2518
• Mol File: 1574-87-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 385°C at 760 mmHg
• Flash Point: 168.6°C
• Density: 1.149g/cm³
• Vapor Pressure: 3.93E-06mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: 4-(4-methoxyphenyl)-5-nitropentan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxyphenyl)-5-nitropentan-2-one(1574-87-4)
• EPA Substance Registry System: 4-(4-methoxyphenyl)-5-nitropentan-2-one(1574-87-4)

Safety Data

• Hazardous Substances Data: 1574-87-4(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 67-64-1 acetone 
• 3179-10-0 (E)-1-methoxy-4-(2-nitrovinyl)benzene 
• 943-88-4 4-(p-methoxyphenyl)-3-butene-2-one 
• 75-52-5 nitromethane 
• 3815-30-3 4-(4-methoxyphenyl)-3-buten-2-one 

Downstream Products

• 91563-34-7 4-(4-methoxy-phenyl)-2-methyl-pyrrolidine 

Relevant articles and documents

Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction

Enzymes are valuable biocatalysts for asymmetric synthesis due to their exacting stereocontrol. Changing the selectivity of an existing catalyst for new applications is, however, challenging. Here we show that, in contrast, the stereoselectivity of an art

Enantiocomplementary synthesis of γ-nitroketones using designed and evolved carboligases

Artificial enzymes created by computational design and directed evolution are versatile biocatalysts whose promiscuous activities represent potentially attractive starting points for divergent evolution in the laboratory. The artificial aldolase RA9S.5-8, for example, exploits amine catalysis to promote mechanistically diverse carboligations. Here we report that RA95.5-8 variants catalyze the asymmetric synthesis of γ-nitroketones via two alternative enantiocomplementary Michael-type reactions: enamine-mediated addition of acetone to nitrostyrenes, and nitroalkane addition to conjugated ketones activated as iminium ions. In addition, a cascade of three aldolasecatalyzed reactions enables one-pot assembly of γ-nitroketones from three simpler building blocks. Together, our results highlight the chemical versatility of artificial aldolases for the practical synthesis of important chiral synthons.

Continuous asymmetric Michael addition of ketones to β-nitroolefins(1R,2R)-(+)-1,2-DPEN-modified sulfonic acid resin

A trifunctional catalyst was successfully prepared by bonding (1R,2R)-(+)-1,2-DPEN to sulfonic acid resin. The catalyst was characterized by elemental analysis, thermogravimetric (TG) analysis and infrared (IR) spectroscopy. The results indicated the coex