1575-17-3

Usage

Indazole derivative

1H-Indazol-5-ol, 1,3-diphenylis a derivative of indazole, a five-membered ring system with one nitrogen atom.

1,3-Diphenyl substitution

The indazole ring is substituted with two phenyl groups (a benzene ring with a hydrogen atom replaced by a methyl group) at the 1 and 3 positions.

Pharmacological effects

1H-Indazol-5-ol, 1,3-diphenylhas been studied for its potential pharmacological effects, including its possible use as an anticancer agent.

Fluorescent probe

It is being researched for its potential as a fluorescent probe in biological studies.

Organic electronics

1H-Indazol-5-ol, 1,3-diphenylhas been investigated for its potential applications in the field of organic electronics due to its unique structural and electronic properties.

Upstream product

• 198772-58-6 2,5-dihydroxybenzophenone phenylhydrazone 
• 588-64-7 benzaldehyde phenylhydrazone 
• 106-51-4 p-benzoquinone 
• 1575-18-4 5-methoxy-1,3-diphenyl-1H-indazole 
• 100-63-0 phenylhydrazine 
• 100-52-7 benzaldehyde 

Downstream Products

• 858490-78-5 4-bromo-1,3-diphenyl-1H-indazol-5-ol 
• 861817-21-2 1,3-diphenyl-1H-indazole-4,5-dione 

Relevant academic research and scientific papers

Synthesis of hybrid polycycles containing fused hydroxy benzofuran and 1H-indazoles via a domino cyclization reaction

A stoichiometry controlled domino cyclization reaction of hydrazone and p-benzoquinone to an angularly fused 3H-benzofuro[3,2-e]indazole core with an embedded oxygenated dibenzofuran framework under mild reaction conditions is disclosed. The reaction involves palladium catalyzed 5-hydroxy-1H-indazole formation followed by TFA mediated [3+2] annulation between the in situ formed 5-hydroxy-1H-indazole and p-benzoquinone. The developed method is attractive because of the concomitant formation of two heterocyclic rings with consecutive multiple bond forming events that include two C-C, one C-N and one C-O bonds. Spectroscopic and theoretical studies of the blue emissive benzofuroindazole derivatives have also been described.

Synthesis of 1,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence

Herein we report a general synthesis of 1,3-diarylsubstituted indazoles utilizing a two-step Suzuki crosscoupling/deprotection/N-arylation sequence. This procedure proceeds in excellent overall yield starting from the 3-iodo-N-Boc indazole derivative allowing for rapid access to these compounds.

The first example of aza-Nenitzescu reaction. A new approach to the heterocyclic quinones synthesis

The first example of aza-Nenitzescu reaction is described. The interaction of azaenamine-benzaldehyde phenylhydrazone with p-benzoquinone and chlorobenzoquinone leads to a new synthesis of 5-hydroxyindazoles and indazole quinones.