157554-76-2

Basic information

• Product Name: N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE
• Synonyms: N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE;N-[4-Bromo-2-nitro-5-(trifluoromethyl)phenyl]-acetamide
• CAS NO: 157554-76-2
• Molecular Formula: C₉H₆BrF₃N₂O₃
• Molecular Weight: 327.06
• Mol File: 157554-76-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE(157554-76-2)
• EPA Substance Registry System: N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE(157554-76-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 157554-76-2(Hazardous Substances Data)

Usage

General Description

N-(4-Bromo-5-(trifluoromethyl)-2-nitrophenyl)acetamide is a chemical compound with the molecular formula C9H6BrF3N2O3. It is a derivative of acetamide, with a nitrophenyl group substituted at the 2-position and a bromine atom at the 4-position of the phenyl ring, and a trifluoromethyl group at the 5-position. N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE has potential applications in pharmaceutical and agricultural industries due to its nitrophenyl moiety, which is known for its diverse biological activities. It may also be used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Additionally, the trifluoromethyl group can impart unique chemical and physical properties, making this compound of interest for further study and potential industrial applications.

Upstream product

• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 41513-05-7 N-(4-bromo-3-trifluoromethylphenyl)acetamide 

Downstream Products

• 157590-60-8 4-bromo-5-(trifluoromethyl)benzene-1,2-diamine 
• 683243-08-5 N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine 
• 683241-86-3 4-bromo-2-nitro-5-(trifluoromethyl)aniline 

Relevant articles and documents

Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H- benzimidazoles

The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2- ylpiperazin-1-yl)-1H-benzo-[d]imidazoles as novel TRPV1 antagonists. Compound 46ad was among the most potent analogues in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA).