157554-76-2

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE is used as an intermediate in the synthesis of various pharmaceuticals for its nitrophenyl moiety, which is known for its diverse biological activities. The trifluoromethyl group also imparts unique chemical and physical properties, making N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE of interest for further study and potential applications in drug development.
Used in Agricultural Industry:
N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE is used as an intermediate in the synthesis of agrochemicals, such as pesticides and herbicides, due to its potential biological activities and unique properties. N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE's structure and functional groups can be further modified to develop new and effective agrochemicals for crop protection and management.

Upstream product

• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 41513-05-7 N-(4-bromo-3-trifluoromethylphenyl)acetamide 

Downstream Products

• 157590-60-8 4-bromo-5-(trifluoromethyl)benzene-1,2-diamine 
• 683243-08-5 N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine 
• 683241-86-3 4-bromo-2-nitro-5-(trifluoromethyl)aniline 

Relevant academic research and scientific papers

Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H- benzimidazoles

The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2- ylpiperazin-1-yl)-1H-benzo-[d]imidazoles as novel TRPV1 antagonists. Compound 46ad was among the most potent analogues in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA).

BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR LIGANDS

Compounds of formula (I) are useful in the treatment of vanilloid-receptor-meditated diseases, such as inflammatory or neuropathic pain and diseases involving sensory nerve function such as asthma, rheumatoid arthritis, osteoarthritis, inflammatory bowel disorders, urinary incontinence, migraine and psoriasis.