157590-60-8

Basic information

• Product Name: 4-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE
• Synonyms: 4-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE;4-Bromo-5-fluorobenzene-1,2-diamine;2-Amino-4-bromo-5-(trifluoromethyl)phenylamine
• CAS NO: 157590-60-8
• Molecular Formula: C₇H₆BrF₃N₂
• Molecular Weight: 255.04
• Mol File: 157590-60-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 284.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.774±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.23±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE(157590-60-8)
• EPA Substance Registry System: 4-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE(157590-60-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 157590-60-8(Hazardous Substances Data)

Usage

General Description

4-Bromo-5-(trifluoromethyl)benzene-1,2-diamine is a chemical compound with the molecular formula C7H6BrF3N2. It is a derivative of benzene, containing a bromine atom and a trifluoromethyl group, as well as two amino groups attached to the benzene ring. 4-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE has potential applications in the field of organic synthesis and pharmaceutical development, particularly as a building block for the synthesis of complex molecules. It may also have uses in the production of dyes and other materials. Additionally, 4-Bromo-5-(trifluoromethyl)benzene-1,2-diamine should be handled with caution, as it may pose health and environmental risks if not properly managed.

Upstream product

• 1028299-41-3 N-(5-bromo-2-nitro-4-(trifluoromethyl)phenyl)acetamide 
• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 157554-76-2 N-[4-bromo-2-nitro-5-(trifluoromethyl)phenyl]acetamide 
• 41513-05-7 N-(4-bromo-3-trifluoromethylphenyl)acetamide 
• 683241-86-3 4-bromo-2-nitro-5-(trifluoromethyl)aniline 
• 1025812-78-5 N-(3-bromo-4-(trifluoromethyl)phenyl)acetamide 
• 172215-91-7 3-bromo-4-(trifluoromethyl)aniline 
• 1026267-58-2 5-Bromo-2-nitro-4-trifluoromethyl-phenylamine 

Downstream Products

• 683243-08-5 N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine 
• 1345117-61-4 2,6-difluoro-N-(5-(6-(trifluoromethyl)benzo[c][1,2,5]thiadiazol-5-yl)pyridin-2-yl)benzamide 

Relevant articles and documents

INDAZOLES AS LRRK2 INHIBITORS

The present invention is directed to indazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

The development of benzimidazoles as selective rho kinase inhibitors

Rho Kinase (ROCK) is a serine/threonine kinase whose inhibition could prove beneficial in numerous therapeutic areas. We have developed a promising class of ATP-competitive inhibitors based upon a benzimidazole scaffold, which show excellent potency toward ROCK (IC50 10 nM). This report details the optimization of selectivity for ROCK over other related kinases such as Protein kinase A (PKA).

Benzimidazole Modulators of VR1

The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.