1575700-07-0Relevant academic research and scientific papers
Regio-Divergent C—H Alkynylation with Janus Directing Strategy via Ir(III) Catalysis
Li, Xianwei,Liang, Guangxin,Shi, Zhang-Jie
supporting information, p. 929 - 934 (2020/06/02)
Directing strategy has been extensively exploited to maintain activity and selectivity for the rapid access to functionalized molecules and pharmaceutical targets. However, ‘one-to-one’ activation model was usually achieved through traditional directing strategy. Herein, we achieved ‘one-to-two’ activation model by slight modification of simple and practical ketoxime and amide functionality. With judicious choice of directing groups, Csp3—H and Csp2—H bond alkynylation reaction, and more significantly, dehydrogenative Csp3—H alkynylation, were realized, enabling the regio-divergent late-stage modifications of pharmaceuticals.
B(C6F5)3-catalyzed hydrogenation of oxime ethers without cleavage of the N-O bond
Mohr, Jens,Oestreich, Martin
supporting information, p. 13278 - 13281 (2015/01/16)
The hydrogenation of oximes and oxime ethers is usually hampered by N-O bond cleavage, hence affording amines rather than hydroxylamines. The boron Lewis acid B(C6F5)3 is found to catalyze the chemoselective hydrogenation
Iridium-catalyzed intermolecular amidation of sp3 C-H bonds: Late-stage functionalization of an unactivated methyl group
Kang, Taek,Kim, Youngchan,Lee, Donggun,Wang, Zhen,Chang, Sukbok
supporting information, p. 4141 - 4144 (2014/04/03)
Reported herein is the iridium-catalyzed direct amidation of unactivated sp3 C-H bonds. With sulfonyl and acyl azides as the amino source, the amidation occurs efficiently under mild conditions over a wide range of unactivated methyl groups with high functional group tolerance. This procedure can be successfully applied for the direct introduction of an amino group into complex compounds and thus can serve as a powerful synthetic tool for late-stage C-H functionalization.
Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp3 methyl C-H bonds
Kang, Taek,Kim, Heejeong,Kim, Jeung Gon,Chang, Sukbok
supporting information, p. 12073 - 12075 (2014/12/11)
Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp3 methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating g
