157641-77-5Relevant academic research and scientific papers
Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase
Sinha, Shweta,Doble, Mukesh,Manju
, p. 34 - 50 (2018)
Human 5-Lipoxygenase (5-LOX) is a key enzyme targeted for asthma and inflammation. Zileuton, the only drug against 5-LOX, was withdrawn from the market due to several problems. In the present study, the performance of rationally designed conjugates of thi
Efficient one-pot synthesis of alkyl 2-(dialkylamino)-4-phenylthiazole-5- carboxylates and single-crystal x-ray structure of methyl 2-(diisopropylamino)- 4-phenylthiazole-5-carboxylate
Souldozi, Ali,Ramazani, Ali,Dadrass, Ali Reza,Slepokura, Katarzyna,Lis, Tadeusz
experimental part, p. 339 - 348 (2012/04/10)
The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylenedicarboxylates (=dialkyl but-2-ynedioates) in the presence of silica gel (SiO2) led to alkyl 2-(dialkylamino)-4-phenylthiazole-5- carboxylates in fairly high yi
