European Journal of Medicinal Chemistry p. 34 - 50 (2018)
Update date:2022-08-15
Topics: Synthesis In vitro IC50 Pharmacophore Analogues Novel Substituted in vivo Design Docking Studies Anti-Inflammatory Spectroscopic Analysis Identification 5-lipoxygenase
Sinha, Shweta
Doble, Mukesh
Manju
Human 5-Lipoxygenase (5-LOX) is a key enzyme targeted for asthma and inflammation. Zileuton, the only drug against 5-LOX, was withdrawn from the market due to several problems. In the present study, the performance of rationally designed conjugates of thi
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Doi:10.1021/ml500008w
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