157650-20-9Relevant academic research and scientific papers
Effects of quercetin and artemetin prenylation on bioavailability and bioactivity
Salamone, Stefano,Nieddu, Mariella,Khalili, Adil,Sansaro, Andrea,Bombardelli, Ezio,Rosa, Antonella,Pollastro, Federica
, (2021/09/27)
Flavonoids are a huge class of polyphenolic compounds ubiquitous in higher plants, in most food and beverages of natural origin. They could be considered as dietary phenols, which exert many health-promoting effects on human and animal physiology with a w
Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative
Mattarei, Andrea,Biasutto, Lucia,Rastrelli, Federico,Garbisa, Spiridione,Marotta, Ester,Zoratti, Mario,Paradisi, Cristina
experimental part, p. 4722 - 4736 (2010/10/20)
The regioselective synthesis of several quercetin (3,3',4',5,7-pentahydroxy flavone) tetraesters bearing a single free OH on 5-C was achieved in good yield by proper choice of reaction conditions using common esterification procedures. Tetracetylated quercetin with the free OH on 7-C was selectively obtained instead via imidazole-promoted deacylation of the corresponding pentaester. Unambiguous structural characterization of the two isomeric tetraacetyl quercetin derivatives was obtained by combined HSQC and HMBC 2D-NMR analysis. These molecules can be used as starting materials for the regioselective synthesis of other derivatives. High yield syntheses of the natural polyphenol rhamnetin (7-O-methylquercetin) and of the new mitochondriotropic compound 7-(4-triphenylphosphoniumbutyl) quercetin iodide are reported as examples.
