1577180-07-4

Basic information

• Product Name: N-(4-((6-bromo-1-methyl-1H-indazol-5-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
• Synonyms: N-(4-((6-bromo-1-methyl-1H-indazol-5-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
• CAS NO: 1577180-07-4
• Molecular Weight: 565.374
• Mol File: 1577180-07-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-((6-bromo-1-methyl-1H-indazol-5-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-((6-bromo-1-methyl-1H-indazol-5-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide(1577180-07-4)
• EPA Substance Registry System: N-(4-((6-bromo-1-methyl-1H-indazol-5-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide(1577180-07-4)

Safety Data

• Hazardous Substances Data: 1577180-07-4(Hazardous Substances Data)

Upstream product

• 1206800-28-3 6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole 
• 1206800-27-2 6-bromo-2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ol 
• 1735-88-2 2-cyano-N-[4-(fluoro)phenyl]acetamide 
• 1206800-25-0 2,4-dibromo-5-(2-fluoro-4-nitrophenoxy) benzaldehyde 
• 1206800-18-1 6-bromo-1H-indazol-5-ol 
• 1206800-17-0 6-bromo-5-methoxy-1H-indazole 
• 1206800-26-1 1-(2,4-dibromo-5-(2-fluoro-4-nitrophenoxy)benzylidene)-2-methylhydrazine 
• 1577180-04-1 C₉H₁₀Br₂N₂O 
• 861084-04-0 5-bromo-4-methoxy-2-methylbenzenamine 
• 371-40-4 4-fluoroaniline 
• 31601-41-9 N-(4-methoxy-2-methylphenyl)acetamide 
• 1206800-24-9 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole 
• 102-50-1 2-methyl-4-methoxyaniline 
• 3111-51-1 2,4-dibromo-5-hydroxybenzaldehyde 

Downstream Products

• 1206801-36-6 tert-butyl 4-(5-(2-fluoro-4-(1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate 
• 1206799-15-6 N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1206800-67-0 3-fluoro-4-(1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yloxy)aniline 

Relevant articles and documents

Route design and development of a MET kinase inhibitor: A copper-catalyzed preparation of an N 1 - Methylindazole

The synthesis of a MET kinase inhibitor in an overall yield of 22% was achieved over eight steps starting with 3-hydroxybenzaldehyde, an improvement from the initial 12-step process with a 5.4% yield. Highlights of the process chemistry design and development are a Cu-catalyzed cyclization to form an important N1-methylindazole ring, a selective nitro reduction in the presence of an aryl bromide, a late-stage Suzuki cross-coupling, and a base-promoted Boc deprotection to form the desired drug candidate.