861084-04-0

Basic information

• Product Name: 5-broMo-4-Methoxy-2-MethylbenzenaMine
• Synonyms: 5-broMo-4-Methoxy-2-MethylbenzenaMine;5-broMo-4-Methoxy-2-Methylaniline;Benzenamine, 5-bromo-4-methoxy-2-methyl-;5-Bromo-4-methoxy-2-methyl-phenylamine
• CAS NO: 861084-04-0
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 216.0751
• Mol File: 861084-04-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 302.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.458±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.98±0.10(Predicted)
• CAS DataBase Reference: 5-broMo-4-Methoxy-2-MethylbenzenaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-4-Methoxy-2-MethylbenzenaMine(861084-04-0)
• EPA Substance Registry System: 5-broMo-4-Methoxy-2-MethylbenzenaMine(861084-04-0)

Safety Data

• Hazardous Substances Data: 861084-04-0(Hazardous Substances Data)

Usage

General Description

5-bromo-4-methoxy-2-methylbenzenamine is a chemical compound with the molecular formula C8H10BrNO. It is a derivative of aniline and is commonly used in the synthesis of pharmaceuticals and other organic compounds. This chemical is a white to light yellow crystalline powder with a molecular weight of 219.08 g/mol. It is primarily used as an intermediate in the production of various pharmaceuticals, dyes, and pigments. 5-broMo-4-Methoxy-2-MethylbenzenaMine is also known to have potential applications in the field of organic chemistry and drug development due to its unique structure and reactivity. However, it is important to handle this chemical with caution as it may pose certain health and safety risks if not properly handled and stored.

Upstream product

• 102-50-1 2-methyl-4-methoxyaniline 
• 31601-41-9 N-(4-methoxy-2-methylphenyl)acetamide 
• 2581-34-2 3-methyl-4-nitrophenol 
• 74-88-4 methyl iodide 
• 14401-60-6 2-bromo-5-methyl-4-nitrophenol 
• 861076-28-0 1-bromo-2-methoxy-4-methyl-5-nitrobenzene 

Downstream Products

• 5456-94-0 2,4-dibromo-5-methylanisole 
• 1206799-15-6 N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1206800-19-2 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1H-indazole 
• 1206801-13-9 6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-methyl-2H-indazole 
• 1206800-42-1 tert-butyl 4-(5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate 
• 1206800-56-7 tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate 
• 1206801-36-6 tert-butyl 4-(5-(2-fluoro-4-(1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate 
• 1206800-24-9 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole 
• 1403767-19-0 6-bromo-1-methyl-1H-indazol-5-ol 
• 1206800-67-0 3-fluoro-4-(1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yloxy)aniline 
• 1577180-07-4 N-(4-((6-bromo-1-methyl-1H-indazol-5-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1206800-17-0 6-bromo-5-methoxy-1H-indazole 
• 1206800-18-1 6-bromo-1H-indazol-5-ol 
• 1206800-27-2 6-bromo-2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ol 

Relevant articles and documents

Discovery of 4-Aminoquinoline-3-carboxamide derivatives as potent reversible Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis

A structure-hopping strategy was applied to discover a series of novel 4-aminoquinoline-3-carboxamide derivatives as potent, reversible BTK inhibitors. Compared to the previously described cinnoline scaffold compounds, the 4-aminoquinoline analogues showed significantly improved drug-like properties, especially in their aqueous solubility. The most potent compound, 25, displayed a stronger inhibitory effect on both BTKWT (IC50 = 5.3 nM) and BTKC481S (IC50 = 39 nM). In a rodent collagen-induced arthritis model, compound 25 efficiently reduced paw swelling without a loss in body weight. On the basis of potency, drug-like properties, stability, and noncovalent mode of inhibition, our representative inhibitors could have a promising profile to be treatments for a wide range of autoimmune diseases.

AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET

The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer.