1577232-63-3

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 105-53-3 diethyl malonate 
• 2689-88-5 diethyl 2,2-di(prop-2-yn-1-yl)malonate 
• 932-87-6 1-Bromo-2-phenylacetylene 

Downstream Products

• 1577232-51-9 diethyl 7-bromo-5-(4-fluorophenyl)-4-((4-fluorophenyl)ethynyl)-1H-indene-2,2(3H)-dicarboxylate 

Relevant academic research and scientific papers

Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone

An unprecedented C═C double bond cleavage of cyclopropenone and dioxygen activation by multiyne cascade coupling has been developed. This chemistry provides a novel, simple, and efficient approach to synthesize fully substituted conjugate benzofuran derivatives from simple substrates under mild conditions. The density functional theory (DFT) calculations reveal that the unique homolytic cleavages of cyclopropenone and molecular oxygen are crucial to the success of this reaction.

Multi-substituted aromatic hydrocarbon derivative and preparation method thereof

The invention provides a multi-substituted aromatic hydrocarbon derivative and a preparation method thereof. Compared with the prior art, the multi-substituted aromatic hydrocarbon derivative is simply, conveniently and efficiently synthesized through reactions such as electron transferring, carbon-carbon bond cracking and the like without a catalyst by using the preparation method from a new angle, and further is short in reaction time and high in reaction efficiency. In addition, the invention provides a series of novel multi-substituted aromatic hydrocarbon derivatives. Compared with a common multi-substituted aromatic hydrocarbon derivative, the multi-substituted aromatic hydrocarbon derivative is relatively complex and diverse in structure and has relatively wide application prospectsin chemical production and clinical medicines.