79147-32-3

Basic information

• Product Name: anhydro(8-ethyl-5-hydroxy-7-oxothiazolo<3,2-a>pyrimidinium hydroxide)
• CAS NO: 79147-32-3
• Molecular Weight: 196.23
• Mol File: 79147-32-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: anhydro(8-ethyl-5-hydroxy-7-oxothiazolo<3,2-a>pyrimidinium hydroxide)(CAS DataBase Reference)
• NIST Chemistry Reference: anhydro(8-ethyl-5-hydroxy-7-oxothiazolo<3,2-a>pyrimidinium hydroxide)(79147-32-3)
• EPA Substance Registry System: anhydro(8-ethyl-5-hydroxy-7-oxothiazolo<3,2-a>pyrimidinium hydroxide)(79147-32-3)

Safety Data

• Hazardous Substances Data: 79147-32-3(Hazardous Substances Data)

Upstream product

• 13472-75-8 2-(2-Aminoethyl)-thiazole 
• 15781-70-1 malonic acid bis-(2,4,6-trichloro-phenyl) ester 

Downstream Products

• 100037-54-5 N-phenyl-N'-(2-thiazolyl)-N'-ethylmalonamide 
• 10255-99-9 N,N'-dibenzyl-malonamide 
• 100037-55-6 N-phenethyl-N'-(2-thiazolyl)-N'-ethylmalonamide 

Relevant articles and documents

Studies of Amine-Induced Ring Opening of Some Mesoionic Xanthines

The ring-opening reactions of seven mesoionic thiazolopyrimidine-5,7-diones by a series of primary and secondary amines have been investigated.The rates of the ring fission of five N(8)-substituted mesoionic xanthines with benzylamine were measured and found to follow second order kinetics.The Hammett relationship is followed with ρ value of +0.48 in p-dioxane as solvent.The dependence of rates on temperatures has been studied for the N(8)-ethyl derivative; the energy of activation (ΔE*) is 25.3 kcals mol-1, the enthalpy of activation (ΔH*) is 24.7 kcals mo l -1 and the entropy of activation (ΔS*) is -4.9 e.u.A slight increase in rate of reaction was observed when the solvent was changed from p-dioxane to dimethyl sulfoxide.In p-dioxane at constant mesoionic xanthine concentration, the rate constant for ring opening decreased with increasing benzylamine concentration.These results are consistent with a bimolecular nucleophilic mechanism proceeding by the rate-determining formation of a charged tetrahedral transition state.