1578245-39-2

Basic information

• Product Name: N²-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine
• CAS NO: 1578245-39-2
• Molecular Weight: 445.567
• Mol File: 1578245-39-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N²-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine(1578245-39-2)
• EPA Substance Registry System: N²-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine(1578245-39-2)

Safety Data

• Hazardous Substances Data: 1578245-39-2(Hazardous Substances Data)

Upstream product

• 24134-09-6 5-bromo-1,2-dimethyl-1H-imidazole 
• 461699-81-0 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1578246-26-0 N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)formamide 
• 1578246-25-9 6-methyl-2-(methylsulfonyl)-N-neopentylpyrido[3,4-d]pyrimidin-8-amine 
• 1578246-24-8 6-methyl-2-(methylthio)-N-neopentylpyrido[3,4-d]pyrimidin-8-amine 
• 5813-64-9 2.2-dimethylpropylamine 

Relevant articles and documents

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N

Monopolar spindle 1 (MPS1) occupies a central role in mitosis and is one of the main components of the spindle assembly checkpoint. The MPS1 kinase is an attractive cancer target, and herein, we report the discovery of the clinical candidate BOS172722. Th