461699-81-0

Basic information

• Product Name: 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER
• Synonyms: 2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ANILINE;4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER;4-Amino-3-methoxybenzeneboronic acid. pinacol ester;4-Amino-3-methoxybenzeneboronic acid,pinacol ester ,97%;2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anisole;4-Amino-3-methoxybenzeneboronicacid,pinacolester98%;2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
• CAS NO: 461699-81-0
• Molecular Formula: C₁₃H₂₀BNO₃
• Molecular Weight: 249.11
• Mol File: 461699-81-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 113-116°C
• Boiling Point: 373.1°Cat760mmHg
• Flash Point: 179.4°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER(461699-81-0)
• EPA Substance Registry System: 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER(461699-81-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 461699-81-0(Hazardous Substances Data)

Usage

General Description

4-Amino-3-Methoxyphenylboronic acid, pinacol ester is a chemical compound that belongs to the class of boronic acid derivatives. It is commonly used in organic synthesis, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER has been of interest to researchers due to its potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. Its unique properties make it a valuable reagent for the construction of complex organic molecules, and it has been studied for its potential use in the synthesis of biologically active compounds. Additionally, it has shown promise in the development of new materials for various industrial applications.

InChI:InChI=1/C13H20BNO3/c1-12(2)13(3,4)18-14(17-12)9-6-7-10(15)11(8-9)16-5/h6-8H,15H2,1-5H3

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 59557-91-4 4-bromo-2-methoxyaniline 
• 73183-34-3 bis(pinacol)diborane 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 121-43-7 Trimethyl borate 
• 226713-38-8 benzhydryliden-(4-bromo-2-methoxyphenyl)-amine 

Downstream Products

• 461697-30-3 N-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-methyl-1H-indole-2-carboxamide 
• 832699-15-7 1-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-indole-2-carboxamide 
• 832699-17-9 N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-methyl-1H-benzimidazole-2-carboxamide 
• 262433-02-3 tert-Butyl N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-carbamate 
• 1140626-74-9 ((1,3-benzothiazol-2-ylmethyl){[2-(4-amino-3-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]carbonyl}amino)acetic acid 
• 1914078-87-7 phenyl N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate 
• 2045409-68-3 N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-phenylacetamide 
• 1032943-47-7 2-methoxy-4-(1-methyl-1H-pyrazolo[3,4-c]pyridin-4-yl)-phenylamine 
• 461702-98-7 N₃-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-3-indolecarboxamide 
• 1079997-35-5 1-[6-(4-Amino-3-methoxy-phenyl)-pyrido[2,3-b]pyrazin-3-yl]-3-ethyl-urea 
• 1534377-39-3 N-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide 

Relevant articles and documents

Para-Selective, Iridium-Catalyzed C-H Borylations of Sulfated Phenols, Benzyl Alcohols, and Anilines Directed by Ion-Pair Electrostatic Interactions

Para C-H borylations (CHB) of tetraalkylammonium sulfates and sulfamates have been achieved using bipyridine-ligated Ir boryl catalysts. Selectivities can be modulated by both the length of the alkyl groups in the tetraalkylammonium cations and the substituents on the bipyridine ligands. Ion pairing, where the alkyl groups of the cation shield the meta C-H bonds in the counteranions, is proposed to account for para selectivity. The 4,4′-dimethoxy-2,2′-bipyridine ligand gave superior selectivities.

RAD51 INHIBITORS

This application is directed to inhibitors of RAD51, and methods for their use, such as to treat or prevent conditions involving mitochondrial defects.

Process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters

The present invention relates to a process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters of formula (I) in high yields The claimed process uses diarylketal formula (V) to generate an arylbromid of formula (III) in which the amino-group is protected as bisarylmethylidenimino-group: