157831-75-9

Basic information

• Product Name: 2-NITRO-5-PIPERIDINOPHENOL
• Synonyms: 2-NITRO-5-PIPERIDINOPHENOL;N-(3-HYDROXY-4-NITROPHENYL)PIPERIDINE;2-NITRO-5-(1-PIPERIDINO)PHENOL, 97%;2-Nitro-5-(1-piperidinyl)phenol, 97%
• CAS NO: 157831-75-9
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.24
• Mol File: 157831-75-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 68-70°C
• Boiling Point: 397.6°Cat760mmHg
• Flash Point: 194.2°C
• Appearance: /
• Density: 1.292g/cm³
• Vapor Pressure: 6.87E-07mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 2-NITRO-5-PIPERIDINOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITRO-5-PIPERIDINOPHENOL(157831-75-9)
• EPA Substance Registry System: 2-NITRO-5-PIPERIDINOPHENOL(157831-75-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 157831-75-9(Hazardous Substances Data)

Usage

General Description

2-NITRO-5-PIPERIDINOPHENOL is a chemical compound commonly used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also known for its ability to inhibit the enzymatic activity of tyrosine kinases, which play a crucial role in the growth and spread of cancer cells. Additionally, this compound has shown potential as an antibacterial and antifungal agent, making it valuable for the development of new therapeutic treatments. However, 2-NITRO-5-PIPERIDINOPHENOL is also considered hazardous due to its potential to cause skin and eye irritation, as well as respiratory problems if inhaled. Therefore, appropriate safety measures should be taken when handling and using this chemical.

InChI:InChI=1/C11H14N2O3/c14-11-8-9(4-5-10(11)13(15)16)12-6-2-1-3-7-12/h4-5,8,14H,1-3,6-7H2

Upstream product

• 110-89-4 piperidine 
• 446-36-6 5-fluoro-2-nitrophenol 

Downstream Products

• 869790-49-8 4-(1-piperidinyl)-2-(2-iodobenzyloxy)aniline 

Relevant articles and documents

Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors

Sphingolipids (SphLs) are a diverse class of molecules that are regulated by a complex network of enzymatic pathways. A disturbance in these pathways leads to lipid accumulation and initiation of several SphL-related disorders. Acid ceramidase is one of the key enzymes that regulate the metabolism of ceramides and glycosphingolipids, which are important members of the SphL family. Herein, we describe the lead optimization studies of benzoxazolone carboxamides resulting in piperidine 22m, where we demonstrated target engagement in two animal models of neuropathic lysosomal storage diseases (LSDs), Gaucher's and Krabbe's diseases. After daily intraperitoneal administration at 90 mg kg-1, 22m significantly reduced the brain levels of the toxic lipids glucosylsphingosine (GluSph) in 4L;C? mice and galactosylsphingosine (GalSph) in Twitcher mice. We believe that 22m is a lead molecule that can be further developed for the correction of severe neurological LSDs where GluSph or GalSph play a significant role in disease pathogenesis.

2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site

2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.