15794-99-7Relevant academic research and scientific papers
Synthesis and biological evaluation of cis-combretastatin analogs and their novel 1,2,3-triazole derivatives
Pati, Hari N.,Wicks, Martha,Holt Jr., Herman L.,LeBlanc, Regan,Weisbruch, Paul,Forrest, Lori,Lee, Moses
, p. 117 - 120 (2007/10/03)
Three cis-combretastatin analogs (8-10) and three novel 1,2,3-triazole derivatives (5-7) have been synthesized. The cis-combretastatins were prepared from selective hydrogenation of the corresponding alkyne. Reaction of the alkyne intermediates with benzy
Elimination Reactions of Stilbene Dibromides. Dehydrobromination by Acetate, Cyanide or Chloride Ions in Dimethylformamide
Avraamides, James,Parker, Alan J.
, p. 1705 - 1717 (2007/10/02)
Rates of dehydrobromination of a series of 4-nitro- and methoxystilbene dibromides by means of acetate, cyanide or chloride ions in dimethylformamide have been measured.A product analysis was performed which indicated a strong preference for anti elimination.Probable transition state structures utilized by each of the three nucleophiles are described.Attack by the base may be at either β-hydrogen (E 2H) or Cα(E2C).The slowest reaction in with chloride ion, which also gives the highest anti/syn elimination product ratio.
