15795-61-6Relevant academic research and scientific papers
Copper-catalysed domino reaction of 2-bromobenzylidenemalonates and 1,3-dicarbonyls for the synthesis of chromenes
Saebang, Yotsakorn,Rukachaisirikul, Vatcharin,Kaeobamrung, Juthanat
, p. 168 - 171 (2017)
4H-Chromenes were synthesized from 2-bromobenzylidenemalonates and 1,3-dicarbonyls under mild and simple reaction conditions via copper-catalysed domino reactions involving Michael addition and intramolecular Ullmann-type C(aryl)–O bond formation. Althoug
A transition metal free expedient approach for the C[dbnd]C bond cleavage of arylidene Meldrum's acid and malononitrile derivatives
Suresh, Muthiah,Kumari, Anusueya,Singh, Raj Bahadur
, (2019/09/10)
A transition metal free expedient approach for the C[dbnd]C bond cleavage of electron deficient alkenes such as arylidene Meldrum's acid and malononitrile derivatives are discussed. The C[dbnd]C bond of these compound were cleaved to benzoic acid in good yield at high temperature. Most importantly, with oxone in CH3CN/H2O at 45 °C or m-CPBA in DCM or NaClO2 in THF/H2O or PIDA in THF at room temperature furnished benzaldehyde derivatives selectively in excellent yields.
A practical and convenient protocol for the synthesis of (E)-α,β-unsaturated acids
Mohite, Amar R.,Bhat, Ramakrishna G.
supporting information, p. 4564 - 4567 (2013/09/24)
α,β-Unsaturated acids are very useful and versatile reagents in organic synthesis. A novel, practical, and convenient catalytic protocol comprising FeCl3·6H2O (0.5 mol %) and H 2O (1 equiv) in CH3NO2 is described for the rapid synthesis of α,β-unsaturated acids with high E-stereoselectivity under both microwave and conventional heating conditions with high TON and TOF values. This powerful approach efficiently demonstrated the utility of biomass derived aldehydes to build chemical agents used as fuel additives. The method proved to be scalable to gram scale synthesis.
Tandem C-C bond-forming processes: Interception of the Pd-catalyzed decarboxylative allylation of allyl diphenylglycinate Lmines with activated olefins
Yeagley, Andrew A.,Lowder, Melissa A.,Chruma, Jason J.
supporting information; experimental part, p. 4022 - 4025 (2009/12/05)
Interception of the Pd-catalyzed decarboxylase allylation of allyl diphenylglycinate imines with appropriately functionalized Michael acceptors, followed by Heck cyclization, allows for the efficient construction of relatively complex organoamine framewor
A general and practical preparation of alkylidene Meldrum's acids
Dumas, Aaron M.,Seed, Adam,Zorzitto, Alexander K.,Fillion, Eric
, p. 7072 - 7074 (2008/03/11)
Although many methods have been reported for the Knoevenagel condensation of aldehydes and Meldrum's acid, most are not general or use unconventional reagents and conditions. We have found that alkylidene Meldrum's acids form readily in benzene solution u
