158010-32-3Relevant academic research and scientific papers
Total synthesis of (+)-rolliniastatin 1
Koert
, p. 2517 - 2520 (2007/10/02)
The first total synthesis of the naturally occurring acetogenin (+)-rolliniastatin 1 (1) has been achieved. A high degree of stereochemical control in the construction of the bis-THF system was accomplished by chelation controlled addition of functionalized organo-metallic reagents derived from 5 and 11 to α-alkoxy-aldehydes.
