158010-31-2

Upstream product

• 100-39-0 benzyl bromide 
• 51268-87-2 (4S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol 
• 42890-78-8 (S)-(-)-isopropylidenedioxybutyl bromide 
• 36326-38-2 3-<(4'S)-2',2'-dimethyl-1',3'-dioxolan-4'-yl>prop-2-enoic acid ethyl ester 
• 111192-54-2 3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid 
• 94944-62-4 (S)-4,5-O-isopropylidene-4,5-dihydroxypentanenitrile 
• 19131-21-6 (2S)-pentane-1,2,5-triol 
• 4344-84-7 5-oxo-tetrahydro-furan-2-carboxylic acid 

Downstream Products

• 172689-02-0 (2S)-5-O-Benzyl-1,2-bis-O-(triisopropylsilyl)pentane-1,2,5-triol 
• 172689-00-8 (2S,5S)-1,2-Bis-O-(triisopropylsilyl)-8-(pivaloyloxy)octane-1,2,5-triol 
• 89872-57-1 (2S)-2,5-dihydroxy-1-tosyloxypentane 
• 334976-37-3 (S)-6-(benzyloxy)hex-1-en-3-ol 
• 1601468-14-7 (S)-6-(benzyloxy)hex-1-en-3-yl 3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)propanoate 
• 1601468-15-8 C₂₁H₃₀O₅ 
• 1601468-16-9 C₂₁H₃₀O₅ 
• 1389347-44-7 (S)-4,5-bis(octadecyloxy)pentyl (4-nitrophenyl)carbonate 
• 158010-32-3 (R)-1-Benzyloxy-14-(tert-butyl-diphenyl-silanyloxy)-tetradecan-4-ol 
• 404936-51-2 2-[(1E,6R,8S)-11-(benzyloxy)-6,8-dihydroxy-1-undecenyl]-6-methoxybenzoic acid 
• 404936-49-8 methyl 2-[(1E,6R,8S)-11-(benzyloxy)-6,8-dihydroxy-6,8-O-isopropylidene-1-undecenyl]-6-methoxybenzoate 
• 404936-50-1 methyl 2-[(1E,6R,8S)-11-(benzyloxy)-6,8-dihydroxy-1-undecenyl]-6-methoxybenzoate 
• 404936-41-0 (6S)-1-triethylsilyloxy-4,4-S-S-propylidene-6-hydroxy-9-benzyloxy-nonane 
• 404936-52-3 (3S,5R)-3-[3-(benzyloxy)propyl]-5-hydroxy-14-methoxy-3,4,5,6,7,8-hexahydro-1H-2-benzoxacyclododecin-1-one 

Relevant academic research and scientific papers

Synthesis of the core structure of apicularen a by transannular cyclization.

[reaction: see text] An approach to the macrocyclic core of apicularen A is described. Thus, cross-coupling of the aryl triflate 7 with the vinylstannane 19 provided the styrene 20. Deprotection led to the dihydroxy acid 22. Through a size-selective macro

Stereoselective total synthesis of cananginones (D-I) using Ireland-Claisen rearrangement as a key step

A strategy for stereoselective total synthesis of α-substituted γ-hydroxymethyl γ-butyrolactone containing bioactive natural products cananginones (D-I) has been developed using cheap and commercially available d-mannitol as a chiral pool. The Ireland-Cla

PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY

The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.

Functionalized Diorganozinc Compounds: Key Reagents for the Synthesis of Enantiomerically Pure 2,5-Disubstituted cis- and trans-Tetrahydrofurans

1,4-Diol derivatives 4a-i were synthesized stereoselectively by either reagent- or catalyst-controlled routes using the addition of functionalized diorganozinc reagents to aldehydes.The stereoselectivities along the reagent-controlled synthetic path were in the range between 80:20 and 95:5.The stereoselectivities along the catalyst route exceeded 95:5.The 1,4-diol derivatives 4 thus obtained were transformed into enantiomerically pure cis- and trans-2,5-disubstituted tetrahydrofurans (16-20) by means of an intramolecular Williamson reaction. - Keywords: Synthesis, stereoselective / Catalysis / Tetrahydrofurans / Dialkylzinc reagents

Total synthesis of (+)-rolliniastatin 1

The first total synthesis of the naturally occurring acetogenin (+)-rolliniastatin 1 (1) has been achieved. A high degree of stereochemical control in the construction of the bis-THF system was accomplished by chelation controlled addition of functionalized organo-metallic reagents derived from 5 and 11 to α-alkoxy-aldehydes.