158040-52-9Relevant academic research and scientific papers
Formal total synthesis of FK506. Concise construction of the C(10)-C(34) segment via an effective coupling tactic
Smith III,Chen,Robinson,Laakso,Hale
, p. 4271 - 4274 (1994)
A formal total synthesis of the potent immunosuppressant FK506 (1) has been achieved via a concise construction of the Merck advanced intermediate (-)-2. Key features of the successful strategy include stereocontrolled σ-bond installation of the trisubsti
