Formal total synthesis of FK506. Concise construction of the C(10)-C(34) segment via an effective coupling tactic

DOI: 10.1016/S0040-4039(00)73331-4

Source and publish data:

Tetrahedron Letters p. 4271 - 4274 (1994)

Update date:2022-08-04

Topics:

Authors:

Smith III

Chen Chen

Robinson

Laakso Laakso

Hale Hale

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)73331-4

A formal total synthesis of the potent immunosuppressant FK506 (1) has been achieved via a concise construction of the Merck advanced intermediate (-)-2. Key features of the successful strategy include stereocontrolled σ-bond installation of the trisubsti

Full text of DOI:10.1016/S0040-4039(00)73331-4

Products guided by the article

Product name:{(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane

Cas No:158040-52-9

R&D Labs maybe for 158040-52-9

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

website:http://www.trustwe.com

Contact:+86-21-61551413

Address:601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong
Ningbo Hi-tech Zone Nice-Synth Chemical Industry Ltd.

Contact:+86-(574)-81110986

Address:No. 1210, Building 3, Wante Business Centre, Hi-tech Zone, Ningbo
Shandong Hongxiang Zinc Co., Ltd

Contact:086-0311-66187879

Address:DaWang developing zone
Wuhan Jadechem International Trade Co.,Ltd.

website:http://www.jadechem-intl.com

Contact:+86-27-83527060

Address:Room 502,Building C11,Software new city No.8,Huacheng Avenue,East Lake High-tech development zone,Wuhan,Hubei,China
Jiangsu Zhenfang Chemical CO.,LTD.(Suzhou Zhenfang Chemical Factory)

Contact:+86-512-69598882

Address:Room1201, Jiayuan Road No.1018, Xiangcheng District, Suzhou, China

Relevant to this article

Explanation of "silver Effects" in Gold(I)-Catalyzed Hydroalkoxylation of Alkynes

Doi:10.1021/acscatal.5b01493
(2015)
Stereoselective Amination of Chiral Enolates: Synthesis of enantiomerically pure α,β-Diamino Acids, Chiral Key Compounds in the Synthesis of Conformationally Constrained Peptido- and Non-peptidomimetics

Doi:10.1016/0957-4166(95)00368-Y
(1995)
Antioxidant activity of novel imidazo[2,1-b]thiazole derivatives: Design, synthesis, biological evaluation, molecular docking study and in silico ADME prediction

Doi:10.1016/j.bioorg.2020.104220
(2020)
Photolytic, autocatalyzed decomposition of benzylic dialkoxy disulfides

Doi:10.1016/j.tetlet.2009.01.115
(2009)
Synthesis of novel 16-spiro steroids: 7-(Aryl)tetrahydro-1H-pyrrolo[1,2-c] [1,3]thiazolo estrone hybrid heterocycles

Doi:10.1016/j.steroids.2014.01.003
(2014)
Doi:10.1007/BF00763332
()

Article Doi