Formal total synthesis of FK506. Concise construction of the C(10)-C(34) segment via an effective coupling tactic

DOI: 10.1016/S0040-4039(00)73331-4

Source and publish data:

Tetrahedron Letters p. 4271 - 4274 (1994)

Update date:2022-08-04

Topics:

Authors:

Smith III

Chen Chen

Robinson

Laakso Laakso

Hale Hale

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Article abstract of DOI:10.1016/S0040-4039(00)73331-4

A formal total synthesis of the potent immunosuppressant FK506 (1) has been achieved via a concise construction of the Merck advanced intermediate (-)-2. Key features of the successful strategy include stereocontrolled σ-bond installation of the trisubsti

Full text of DOI:10.1016/S0040-4039(00)73331-4

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