158066-06-9Relevant academic research and scientific papers
Gram-Scale Synthesis of a Hexapeptide by Fragment Coupling in a Ball Mill
Lamaty, Frédéric,Métro, Thomas-Xavier,Martinez, Jean,Rguioueg, Nadia,Subra, Gilles,Yeboue, Yves
supporting information, (2021/09/20)
Synthesis of long peptides is generally considered as a challenge to peptide chemists, in addition to producing significant amounts of toxic waste, such as DMF. Here we show that using solvent-less methods, such as ball milling, enabled the production of
Hydrogen bond surrogate stabilized water soluble 310-helix from a disordered pentapeptide containing coded α-amino acids
Pal, Sunit,Prabhakaran, Erode N.
, p. 2515 - 2519 (2018/05/28)
Replacing a hypothetical i + 3 → i peptide H-bond in a disordered pentapeptide, that lacks any helicogenic Cα-tetrasubstituted residues, with a propyl linker and carbamylating the N-terminal nitrogen constrains it in the elusive 310-helical structure with high helicity and stability under varying conditions of temperature and pH, confirmed by NMR and CD analyses.
Peptide Mechanosynthesis by Direct Coupling of N-Protected α-Amino Acids with Amino Esters
Porte, Vincent,Thioloy, Marion,Pigoux, Titouan,Métro, Thomas-Xavier,Martinez, Jean,Lamaty, Frédéric
supporting information, p. 3505 - 3508 (2016/07/28)
In view of developing alternatives to classical peptide synthesis strategies that suffer from low efficacy and negative environmental impact, the reactivity of N-protected α-amino acids, amino esters, and N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide was
COMPOUNDS FOR AMIDE-FORMING REACTIONS
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Page/Page column 11; 18; 26; 27, (2014/01/07)
Provided herein is a compound of Formula I, that displays remarkable physicochemical properties as a peptide-coupling additive for peptide-forming reactions in water, wherein said coupling reactions proceed without measurable racemization. A method of pro
A new oxyma derivative for nonracemizable amide-forming reactions in water
Wang, Qinghui,Wang, Yong,Kurosu, Michio
supporting information; experimental part, p. 3372 - 3375 (2012/09/07)
An Oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (2), displayed remarkable physicochemical properties as a peptide-coupling additive for peptide-forming reactions in water. Short peptides to oligopeptides could b
