158089-31-7Relevant academic research and scientific papers
ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS
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, (2021/10/15)
Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).
A New Class of Nonpeptide Bradykinin B2 Receptor Ligand, Incorporating a 4-Aminoquinoline Framework. Identification of a Key Pharmacophore to Determine Species Difference and Agonist/Antagonist Profile
Sawada, Yuki,Kayakiri, Hiroshi,Abe, Yoshito,Mizutani, Tsuyoshi,Inamura, Noriaki,Asano, Masayuki,Aramori, Ichiro,Hatori, Chie,Oku, Teruo,Tanaka, Hirokazu
, p. 2667 - 2677 (2007/10/03)
Introduction of various aliphatic amino groups at the 4-position of the quinoline moiety of our nonpeptide bradykinin (BK) B2 receptor antagonists afforded highly potent ligands for human B2 receptor with various affinities for guine
5-SUBSTITUTED IMIDAZO[4,5-C]PYRIDINES
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, (2008/06/13)
The present invention relates to a class of compounds represented by the formula STR1 or a pharmaceutically acceptable salt thereof useful in the treatment of diseases or disorders mediated by platelet activating factor (PAF).
REGIOSELECTIVE LITHIATION OF Π-(ARENE)CHROMIUM TRICARBONYL COMPLEXES
Uemura, Motokazu,Nishikawa, Naomi,Hayashi, Yuji
, p. 2069 - 2072 (2007/10/02)
Chromium tricarbonyl complexes of 3-methoxybenzyl alcohol and related compounds were selectively lithiated at the 4-position in contrast to the corresponding metal free arene compounds.The resulting 4-lithio complexes were converted to the 4-substituted arene compounds in moderate to excellent yields through the reaction with proper electrophiles and subsequent demetalation.
