57757-74-1

Upstream product

• 186581-53-3 diazomethane 
• 124-38-9 carbon dioxide 
• 6971-51-3 3-methoxybenzyl alcohol 
• 158089-31-7 4-(hydroxymethyl)-2-methoxybenzoic acid 
• 52520-37-3 (3-Methoxybenzyl alcohol)chromium Tricarbonyl 
• 50-85-1 2-hydroxy-p-toluic acid 
• 189094-76-6 methyl 4-[(acetyloxy)methyl]-2-methoxybenzoate 
• 4670-56-8 methyl 2-hydroxy-4-methylbenzoate 
• 81245-24-1 methyl 4-methyl-2-methoxybenzoate 
• 74733-27-0 methyl 4-bromomethyl-2-methoxybenzoate 

Downstream Products

• 55204-14-3 methyl 4-formyl-2-methoxybenzoate 
• 1351169-42-0 methyl 2-(3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethoxy]acetamido}propoxy)-4-[(E)-3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]benzoate 
• 1351169-27-1 2-[3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethoxy}acetamido)propoxy]-4-[(E)-3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid 
• 1351169-43-1 (S,E)-methyl 4-[3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]-2-(3-{2-[2-(2-{2-[4-methyl-2-(4-phenylbutanamido)pentanamido]ethoxy}ethoxy)ethoxy]acetamido}propoxy)benzoate 
• 1351169-28-2 (S,E)-4-[3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]-2-(3-{2-[2-(2-{2-[4-methyl-2-(4-phenylbutanamido)pentanamido]ethoxy}ethoxy)ethoxy]acetamido}propoxy)benzoic acid 
• 1351169-33-9 C₂₆H₃₂O₄ 
• 1351169-34-0 C₂₅H₃₁BrO₄ 
• 1351169-35-1 (E)-methyl 4-[3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]-2-hydroxybenzoate 
• 1351169-36-2 (E)-methyl 2-[3-(tert-butoxycarbonylamino)propoxy]-4-[3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]benzoate 
• 1351169-37-3 (E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOUNDS

This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers

Compounds that regulate the function(s) of nuclear receptors (NRs) are useful for biological studies and as candidate therapeutic agents. Most such compounds are agonists or antagonists. On the other hand, we have developed specific protein degradation in

PIPERIDINE DERIVATIVES AS HUMAN PAPILLOMA VIRUS INHIBITORS

HPV inhibitors with formula (I) where G1 represents a hydrocarbonated bond or chain possibly substituted by one or two alkyl groups, G2 represents a group (see formula Ia+Ib) or R represents a hydrogen, an alkyl, halogenoalkyl, or a prodrug radical such as carbamate, acetyl or dialkylaminomethyl, G represents a bond or a hydrocarbonated chain possibly substituted by one or two alkyls, W represents an oxygen or sulphur, R1 and R2 each represent a group chosen from among hydrogen, halogen, hydroxyl, thio, alkoxy, halogenoalkoxy, alkylthio, halogenoalkylthio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or halogenoalkyl, R3 represents an acid or a prodrug radical of the acid function or a bioisostere of the acid function, A represents an aryl, cycloalkyl, cycloalkenyl or a heterocycle, each possibly substituted, and B represents an aryl or a heterocycle with 6 chains, each possibly substituted, and pharmaceutically acceptable salts.

Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use

Compounds of formula (I): STR1 wherein: R1 is alkyl; R2a, R2b, R2c and R2d are the same or different and each is hydrogen, optionally substituted alkyl, --(C=O)--B1 (wherein B1 i

Directed regioselective lithiation of (η6-arene) chromium tricarbonyl complexes. Regioselective synthesis of anthraquinones and calamenenes

(3-Methoxybenzylalcohol)chromium tricarbonyl (10) and (7-methoxy-1-tetralol)chromium tricarbonyl (12) are selectively lithiated at the 4- and 6-positions, respectively, by treatment with n-BuLi-TMEDA. Since the directed lithiation of the corresponding chromium free arenes normally proceeds at the 2-and 8-positions, complementarily substituted arenes can be prepared by using the chromium tricarbonyl complexes. The difierent position of lithiation is explained by the relative configuration of the chromium tricarbonyl group in the (arene)Cr(CO)3 and electrostatic factors. Some anthraquinones, 31,36,42, and 7-hydroxycalamenenes, 43, have been synthesized through the stereo- and regioselective introduction of substituents by means of(η6-arene)chromium tricarbonyl complexes.

Arene-Metal Complex in Organic Synthesis: Directed Regioselective Lithiation of (?-Substituted benzene)chromium Tricarbonyl Complexes

(3-Methoxybenzyl alcohol)chromium tricarbonyl complex (8) and (2-substituted 7-methoxy-1-tetralol)chromium complexes 14-17 are selectively lithiated at the 4-position and 6-position, respectively, by treatment with n-BuLi/TMEDA.The regioselectivity of this lithiation is improved with increasing bulk of the butyllithium reagent employed.Since the direct lithiation of the corresponding chromium-free arenes normally proceeds at the 2- and 8-positions, complementarily substituted arenes can be prepared by using chromium tricarbonyl complexes.The different lithiation is explained by the relative configuration of the chromium tricarbonyl group in the (?-arene)Cr(CO)3 complexes and the electrostatic factor.This rationalization is supported, at least in part, by X-ray crystallography of the complex 16.On the other hand, the chromium complexes of arenes without a free hydroxyl group, such as benzyl methyl ether or ethylene acetals of benzaldehydes, are lithiated at the 2-position preferentially.

REGIOSELECTIVE LITHIATION OF Π-(ARENE)CHROMIUM TRICARBONYL COMPLEXES

Chromium tricarbonyl complexes of 3-methoxybenzyl alcohol and related compounds were selectively lithiated at the 4-position in contrast to the corresponding metal free arene compounds.The resulting 4-lithio complexes were converted to the 4-substituted arene compounds in moderate to excellent yields through the reaction with proper electrophiles and subsequent demetalation.