158109-41-2Relevant academic research and scientific papers
PHARMACOLOGICAL PROPERTIES OF NOVEL GLYCOPEPTIDES OF GLYCYRRHIZIC ACID
Davydova, V. A.,Zarudii, F. S.,Baltina, L. A.,Ryzhova, S. A.,Tolstikov, G. A.
, p. 45 - 48 (2007/10/03)
The pharmacological properties of a number of novel glycopeptides of glycyrrhizic acid containing fragments of methyl esters of L-amino acids and dipeptides were studied.The compounds were found to have a low toxicity with anti-inflammatory activity combined with an anti-ulcer effect.This distinguishes these compounds from known anti-inflammatory agents.The synthesis of three novel glycopeptides containing the fragments L-Glu(OMe)2, L-Pro(OMe), and NHCH2(CH)4COOMe is described.
TRANSFORMATIONS OF GLYCYRRHIZIC ACID. VI. NEW METHOD FOR PREPARATION OF CARBOXY-PROTECTED GLYCOPEPTIDES
Baltina, L. A.,Ryzhova, S. A.,Vasil'eva, E. V.,Kapina, A. P.,Tolstikov, G. A.
, p. 1490 - 1495 (2007/10/02)
We developed a new selective technique for synthesizing carboxy-protected glycopeptides of glycyrrhizic acid by condensing glycosides with unprotected hydroxy groups and esters of amino acids using an activated ester prepared by treating glycyrrhizic acid with N-hydroxybenzotriazole and N,N-dicyclohexylcarbodiimide.The yields of the target products were 79-95percent.
