1581275-16-2

Basic information

• Product Name: 5-(4-(3-(cyclopentenyl)benzyl)piperazin-1-yl)-1H-benzo[d]imidazol-2(3H)-one
• Synonyms: 5-(4-(3-(cyclopentenyl)benzyl)piperazin-1-yl)-1H-benzo[d]imidazol-2(3H)-one
• CAS NO: 1581275-16-2
• Molecular Weight: 374.486
• Mol File: 1581275-16-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-(3-(cyclopentenyl)benzyl)piperazin-1-yl)-1H-benzo[d]imidazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-(3-(cyclopentenyl)benzyl)piperazin-1-yl)-1H-benzo[d]imidazol-2(3H)-one(1581275-16-2)
• EPA Substance Registry System: 5-(4-(3-(cyclopentenyl)benzyl)piperazin-1-yl)-1H-benzo[d]imidazol-2(3H)-one(1581275-16-2)

Safety Data

• Hazardous Substances Data: 1581275-16-2(Hazardous Substances Data)

Upstream product

• 1581275-04-8 tert-butyl 4-(4-acetylamino-3-nitrophenyl)piperazine-1-carboxylate 
• 881-50-5 N-(4-bromo-2-nitrophenyl)acetamide 
• 680203-54-7 3-cyclopenten-1-yl-benzaldehyde 
• 1581274-98-7 5-(piperazin-1-yl)-1H-benzo[d]imidazol-2(3H)-one trifluoroacetate 
• 1581275-03-7 tert-butyl 4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)piperazine-1-carboxylate 
• 193902-99-7 tert-butyl 4-(3,4-diaminophenyl)piperazine-1-carboxylate 
• 1581275-05-9 tert-butyl 4-(4-amino-3-nitrophenyl)piperazine-1-carboxylate 

Relevant articles and documents

Benzo[D]imidazole derivatives of piperidine and piperazine

The benzo[d]imidazole derivatives of piperidine and piperazine are 5-piperazinyl and 5-piperadinyl-1H-benzo[d]imidazol-2(3H)-ones that exhibit D2 and 5-HT1A receptor binding affinities, making them suitable for use as the active ingredient of pharmaceuticals for the treatment of schizophrenia. The derivatives have the general formula: where X is carbon or nitrogen and R is a selected biaryl group, or a pharmaceutically acceptable salt thereof. The piperidinyl compounds are prepared by removal of the Boc group from tert-Butyl-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)piperidine-1-carboxylate. Subsequent reductive amination with a selected biarylaldehyde completes the synthesis of the 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones. The piperazinyl compounds are prepared by preparation of the intermediate tert-Butyl 4-(3,4-diaminophenyl)piperazine-1-carboxylate. Removal of the Boc group and subsequent reductive amination with a selected biarylaldehyde completes the synthesis of the 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones.