15815-97-1

Upstream product

• 17630-76-1 5-chloroindole 2,3-dione 
• 24284-35-3 5-chloro-3-hydroxy-3-phenyl-3H-indol-2-one 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 52181-34-7 5-chloro-3-methyl-3-phenyl-1,3-dihydro-indol-2-one 
• 1243153-73-2 (S)-5-chloro-3-hydroxy-3-phenylindolin-2-one 
• 1243153-75-4 (S)-2-amino-5-chloro-3-hydroxy-3-phenylindole 
• 448255-54-7 3-(2-benzoyl-4-chlorophenyl)-1,1-dimethylurea 
• 1399290-75-5 tert-butyl 5-chloro-2-oxo-3-phenylindoline-1-carboxylate 

Relevant academic research and scientific papers

Organocatalytic stereoselective conjugate addition of 3-substituted oxindoles with in situ generated ortho-quinone methides

A novel method for the stereoselective conjugate addition of 3-substituted oxindoles to in situ generated o-QMs was described. This process was catalyzed efficiently by a cinchonidine-derived squaramide catalyst in oil-water phase, furnishing the corresponding 3,3-disubsituted oxindole derivatives in moderate to high yields (up to 98%) with high stereoselectivities (up to 95% ee, 15.4:1 dr). The utility of this reaction was also investigated by the gram-scale synthesis and derivatization of one of the products.

2-AMINOINDOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA

The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)- The values and preferred values of the variables in Structural Formula I are defined herein.