Cas 1243153-75-4,(S)-2-amino-5-chloro-3-hydroxy-3-phenylindole

1243153-75-4

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Basic information

Product Name: (S)-2-amino-5-chloro-3-hydroxy-3-phenylindole
Synonyms: (S)-2-amino-5-chloro-3-hydroxy-3-phenylindole
CAS NO:1243153-75-4
Molecular Formula:
Molecular Weight: 258.707
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (S)-2-amino-5-chloro-3-hydroxy-3-phenylindole(CAS DataBase Reference)
NIST Chemistry Reference: (S)-2-amino-5-chloro-3-hydroxy-3-phenylindole(1243153-75-4)
EPA Substance Registry System: (S)-2-amino-5-chloro-3-hydroxy-3-phenylindole(1243153-75-4)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1243153-75-4(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1243153-75-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,3,1,5 and 3 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1243153-75:
(9*1)+(8*2)+(7*4)+(6*3)+(5*1)+(4*5)+(3*3)+(2*7)+(1*5)=124
124 % 10 = 4
So 1243153-75-4 is a valid CAS Registry Number.

1243153-75-4Upstream product

1243153-75-4Downstream Products

1243153-75-4Relevant academic research and scientific papers

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum

Barker Jr., Robert H.,Urgaonkar, Sameer,Mazitschek, Ralph,Celatka, Cassandra,Skerlj, Renato,Cortese, Joseph F.,Tyndall, Erin,Liu, Hanlan,Cromwell, Mandy,Sidhu, Amar Bir,Guerrero-Bravo, Jose E.,Crespo-Llado, Keila N.,Serrano, Adelfa E.,Lin, Jing-Wen,Janse, Chris J.,Khan, Shahid M.,Duraisingh, Manoj,Coleman, Bradley I.,Angulo-Barturen, Inigo,Jimenez-Diaz, Maria Belen,Magan, Noemi,Gomez, Vanesa,Ferrer, Santiago,Martinez, Maria Santos,Wittlin, Sergio,Papastogiannidis, Petros,O'Shea, Thomas,Klinger, Jeffrey D.,Bree, Mark,Lee, Edward,Levine, Mikaela,Wiegand, Roger C.,Munoz, Benito,Wirth, Dyann F.,Clardy, Jon,Bathurst, Ian,Sybertz, Edmund

, p. 2612 - 2622 (2011)

This study characterizes aminoindole molecules that are analogs of Genz-644442. Genz-644442 was identified as a hit in a screen of ～70,000 compounds in the Broad Institute's small-molecule library and the ICCB-L compound collection at Harvard Medical Scho

2-AMINOINDOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA

-

Page/Page column 86, (2011/05/11)

The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)- The values and preferred values of the variables in Structural Formula I are defined herein.

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity

Urgaonkar, Sameer,Cortese, Joseph F.,Barker, Robert H.,Cromwell, Mandy,Serrano, Adelfa E.,Wirth, Dyann F.,Clardy, Jon,Mazitschek, Ralph

supporting information; experimental part, p. 3998 - 4001 (2010/10/21)

The development of a concise strategy to access 2-amino-3-hydroxy-indoles, which are disclosed as novel antimalarials with potent in vivo activity, is reported. Starting from isatins the target compounds are synthesized in 2 steps and in good yields via oxoindole intermediates by employing tert- butyldimethylsilyl amine (TBDMSNH2) as previously unexplored ammonia equivalent.

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