158226-80-3

Upstream product

• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 68572-75-8 diethyl (4R,5R)-2-(4-methoxyphenyl)-1,3-dioxolane-4,5-dicarboxylate 

Downstream Products

• 1054786-44-5 (R)-3-Hydroxy-3-[(2R,4S,5S)-5-methoxy-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-2,2-dimethyl-propionic acid methyl ester 
• 158226-85-8 (2R,4R,5S)-5-Methoxy-2-(4-methoxy-phenyl)-[1,3]dioxane-4-carbaldehyde 
• 158226-83-6 [(2R,4S,5S)-5-Methoxy-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-methanol 
• 158226-82-5 (2S,3S)-2-Methoxy-3-(4-methoxy-benzyloxy)-butane-1,4-diol 
• 158226-81-4 (2R,3R)-2-Methoxy-3-(4-methoxy-benzyloxy)-succinic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis of the C13-C19 unit in the spiroketal fragment of calyculins

Synthesis of the C13-C19 unit 2 of calyculins (1) has been accomplished by use of the stereoselective aldol reaction of the aldehyde 10 from diethyl L-tartrate (3) with methyl trimethylsilyl dimethylketene acetal followed by the introduction of a cyano group as a C1-unit.