15825-89-5

Basic information

• Product Name: Pyridine, 3-(1-Methylethenyl)-
• Synonyms: Pyridine, 3-(1-Methylethenyl)-
• CAS NO: 15825-89-5
• Molecular Formula: C₈H₉N
• Molecular Weight: 119.16376
• Mol File: 15825-89-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine, 3-(1-Methylethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-(1-Methylethenyl)-(15825-89-5)
• EPA Substance Registry System: Pyridine, 3-(1-Methylethenyl)-(15825-89-5)

Safety Data

• Hazardous Substances Data: 15825-89-5(Hazardous Substances Data)

Upstream product

• 15031-77-3 2-(3-pyridinyl)-2-propanol 
• 626-60-8 3-Chloropyridine 
• 108-22-5 Isopropenyl acetate 
• 350-03-8 methyl-3-pyridylketone 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 626-55-1 3-Bromopyridine 
• 75-24-1 trimethylaluminum 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 54-36-4 metyrapone 
• 557-93-7 2-bromoprop-1-ene 
• 89878-14-8 3-Diethylboranylpyridine 

Downstream Products

• 38031-78-6 3-tert-butylpyridine 
• 350-03-8 methyl-3-pyridylketone 
• 1308661-37-1 2-(pyridin-3-yl)-1-tosylpropan-2-ol 

Relevant articles and documents

Synthesis of N-Alkylpyridin-4-ones and Thiazolo[3,2- a]pyridin-5-ones through Pummerer-Type Reactions

N-Alkylated 4-pyridones were obtained through a one-pot procedure involving either normal or interrupted Pummerer reactions between triflic anhydride-activated sulfoxides and 4-fluoropyridine derivatives, followed by hydrolysis. On the other hand, triflic anhydride-activated benzyl 6-fluoro-2-pyridyl sulfoxide could react with alkenes or alkynes to afford thiazolo[3,2-a]pyridin-5-ones, via the pyridinium salt intermediates.

Expedient synthesis of gem-dialkylbenzyl heterocycles through olefinic hydroarylation

A robust approach to gem-dialkylbenzyl heterocycles has been developed through a triflic acid-catalyzed hydroarylation of olefinic heterocycles. A broad range of substrates containing pyridine, quinoline, pyrazole, triazole and imidazole moieties are shown to be highly compatible with this method. This rapid construction of gem-dialkyl groups should be useful in the synthesis of drug-like molecules containing heterocyclic diversity and in the study of the gem-dialkyl effect.

Access to "friedel-Crafts-Restricted" tert -alkyl aromatics by activation/methylation of tertiary benzylic alcohols

Herein we describe a two-step protocol to prepare m-tert-alkylbenzenes. The appropriate tertiary benzylic alcohols are activated with SOCl2 or concentrated HCl and then treated with trimethylaluminum, affording the desired products in 68-97% yields (22 examples). This reaction sequence is successful in the presence of a variety of functional groups, including acid-sensitive and Lewis-basic groups. In addition to t-Bu groups, 1,1-dimethylpropyl and 1-ethyl-1-methylpropyl groups can also be installed using this method.