158358-22-6Relevant articles and documents
Asymmetric synthesis of (S)-bufuralol and a propafenone analogue
Zaidlewicz, Marek,Tafelska-Kaczmarek, Agnieszka,Prewysz-Kwinto, Andrzej,Chechlowska, Aldona
, p. 1659 - 1664 (2003)
Asymmetric synthesis of (S)-bufuralol of 87% ee from 3-ethyl-2-hydroxybenzaldehyde, via the reduction of 2-bromo-1-(7-ethylbenzofuran-2-yl)ethanone with (-)-B-chlorodiisopinocampheylborane as the key step, followed by cyclization of the product bromohydrin to the corresponding epoxide and treatment with tert-butylamine, is described. (S)-1-(3-Phenethylbenzofuran-2-yl)-2-propylaminoethanol of 73% ee, a propafenone analogue, was prepared following the same approach.