GE 68

Base Information

• Chemical Name: GE 68
• CAS No.: 158358-22-6
• Molecular Formula: C21H25NO2
• Molecular Weight: 0
• Mol file: 158358-22-6.mol

Synonyms:GE 68

Chemical Property of GE 68

Chemical Property:

• Vapor Pressure: 7.32E-10mmHg at 25°C
• Boiling Point: 475.8°C at 760 mmHg
• Flash Point: 241.6°C
• PSA: 45.40000
• Density: 1.118g/cm³
• LogP: 4.64190

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GE 68

There total 6 articles about GE 68 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propylamine (107-10-8,42939-71-9) + 2-bromo-1-(3-phenethyl-benzofuran-2-yl)ethanone (158358-17-9) → (R)-(+)-1-(3-phenethylbenzofuran-2-yl)-2-propylaminoethanol (158358-22-6) + (S)-(-)-1-(3-phenethylbenzofuran-2-yl)-2-propylaminoethanol (158358-22-6)

Guidance literature:

2-bromo-1-(3-phenethyl-benzofuran-2-yl)ethanone; With (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; at 20 ℃; for 18h;

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 20h;

propylamine; at 70 ℃; for 20h; Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(03)00276-3

Reference yield:

propylamine (107-10-8,42939-71-9) + 2-bromo-1-(3-phenethyl-benzofuran-2-yl)ethanone (158358-17-9) → (R)-(+)-1-(3-phenethylbenzofuran-2-yl)-2-propylaminoethanol (158358-22-6) + (S)-(-)-1-(3-phenethylbenzofuran-2-yl)-2-propylaminoethanol (158358-22-6)

Guidance literature:

2-bromo-1-(3-phenethyl-benzofuran-2-yl)ethanone; With (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; at 20 ℃; for 18h;

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 20h;

propylamine; at 70 ℃; for 20h; Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(03)00276-3

Reference yield:

3-(2-phenylethyl)benzofuran (85148-33-0) → (R)-(+)-1-(3-phenethylbenzofuran-2-yl)-2-propylaminoethanol (158358-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 46 percent / BF₃*Et₂O / 10 h / 50 °C

2.1: 62 percent / pyridinium tribromide; acetic acid / 4 h / 50 - 55 °C

3.1: (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 18 h / 20 °C

3.2: NaH / tetrahydrofuran / 20 h / 20 °C

3.3: 20 h / 70 °C

With boron trifluoride diethyl etherate; acetic acid; pyridinium hydrobromide perbromide; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran;

DOI:10.1016/S0957-4166(03)00276-3

upstream raw materials:

propylamine

2-bromo-1-(3-phenethyl-benzofuran-2-yl)ethanone

3-(2-phenylethyl)benzofuran

1-(3-phenylethylbenzofuran-2-yl)ethan-1-one