15839-44-8

Upstream product

• 19980-43-9 1-(trimethylsilyloxy)cyclopentene 
• 149-73-5 trimethyl orthoformate 
• 67-56-1 methanol 
• 1192-54-7 2-formylcyclopentanone 
• 120-92-3 cyclopentanone 
• 930-91-6 2-hydroxymethylenecyclopentanone 

Downstream Products

• 333994-26-6 2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazole 

Relevant academic research and scientific papers

Efficient syntheses of 2-(2,6-dichloro-4-trifluoromethyl-phenyl)tetrahydrocyclopenta, tetrahydrothiopyrano, hexahydrocycloheptapyrazoles and tetrahydroindazoles

Two methods are described for the regiospecific synthesis of 3,4-fused-cycloalkyl-1-arylpyrazoles; the key step is the reaction between aryl hydrazines and cyclic α-(dimethoxymethyl)ketones. The latter are obtained by BF3-promoted alkylation of ketones with trimethylorthoformate.

Partial reduction of annulated heterocycles as a general route to medium rings containing oxygen and nitrogen.

The preparation of annulated furans and pyrroles is described as part of a general strategy for the synthesis of medium ring heterocycles. After Birch reduction, the corresponding dihydro compounds were oxidatively cleaved to produce medium ring ethers an

Stereoselective Cross-Aldol Reactions of Silyl Enol Ethers with Acetals Catalyzed by Iodotrimethylsilane

Iodotrimethylsilane catalyzes effectively erythroselective aldol type condensation of silyl enol ethers with acetals.

REGIOSPECIFIC α-DIALKOXYMETHYLATION OF PREFORMED ENOLATES

Reaction of a preformed lithium enolate and trimethyl ortoformate with added boron trifluoride leads to the corresponding α-dimethoxymethyl ketone.

Chemistry of enol ethers. LI. Reaction of vinyl silyl ethers with orthoformic esters

The silyl ethers of enolic forms of ketones react with orthoformates in the presence of zinc chloride at catalyst to form β-ketoacetals.The analogous reaction with the silyl ethers of enolic forms of aldehydes leads to the formation of the tetraacetals of 1,3-dialdehydes.