158436-80-7Relevant academic research and scientific papers
ENANTIOSELECTIVE SYNTHESIS OF SUBSTITUTED OCTALONES
Sequeira, Lucia C.,Costa, Paulo R. R.,Neves, Alexandre,Esteves, Pierre
, p. 1433 - 1434 (1994)
The octalones (R)-(-)-1a and (S)-(-)-1b were prepared from the Michael adducts 7a and 7b respectively.These intermediates were obtained by the "deracemizing alkylation" of cyclanones 3a and 3b.
Stereoselective Bulk Synthesis of CCR2 Antagonist BMS-741672: Assembly of an All-cis (S,R,R)-1,2,4-Triaminocyclohexane (TACH) Core via Sequential Heterogeneous Asymmetric Hydrogenations
Deerberg, Joerg,Prasad, Siva J.,Sfouggatakis, Chris,Eastgate, Martin D.,Fan, Yu,Chidambaram, Ramakrishnan,Sharma, Praveen,Li, Li,Schild, Richard,Müslehiddino?lu, Jale,Chung, Hyei-Jha,Leung, Simon,Rosso, Victor
, p. 1949 - 1966 (2017/02/10)
A concise bulk synthesis of stereochemically complex CCR2 antagonist BMS-741672 is reported. A distinct structural feature is the chiral all-cis 1,2,4-triaminocyclohexane (TACH) core, which was assembled through consecutive stereocontrolled heterogeneous
γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists
Cherney, Robert J.,Mo, Ruowei,Meyer, Dayton T.,Voss, Matthew E.,Yang, Michael G.,Santella III, Joseph B.,Duncia, John V.,Lo, Yvonne C.,Yang, Gengjie,Miller, Persymphonie B.,Scherle, Peggy A.,Zhao, Qihong,Mandlekar, Sandhya,Cvijic, Mary Ellen,Barrish, Joel C.,Decicco, Carl P.,Carter, Percy H.
scheme or table, p. 2425 - 2430 (2010/08/05)
We describe the design, synthesis, and evaluation, of γ-lactams as glycinamide replacements within a series of di- and trisubstituted cyclohexane CCR2 antagonists. The lactam-containing trisubstituted cyclohexanes proved to be more potent than the disubst
Cyclic derivatives as modulators of chemokine receptor activity
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Page/Page column 108, (2008/06/13)
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
