1585185-07-4Relevant academic research and scientific papers
Kinetic resolution of 2-substituted 2,3-dihydro-4-pyridones by palladium-catalyzed asymmetric allylic alkylation: Catalytic asymmetric total synthesis of indolizidine (-)-209I
Lei, Bai-Lin,Zhang, Qing-Song,Yu, Wei-Hua,Ding, Qiu-Ping,Ding, Chang-Hua,Hou, Xue-Long
, p. 1944 - 1947 (2014/05/06)
The kinetic resolution of 2-substituted-2,3-dihydro-4-pyridones was realized via a Pd-catalyzed allylic substitution reaction using a commercially available (S)-P-Phos as a ligand, affording optically active dihydropyridones and C-allylated dihydropyridones in high yields and good enantioselectivities with the S-factor up to 43. With this protocol, a catalytic asymmetric total synthesis of indolizidine (-)-209I was realized for the first time.
