158531-82-9Relevant academic research and scientific papers
A novel oxidative cyclization of 2′-hydroxychalcones to 4-methoxyaurones by thallium (III) nitrate
Thakkar, Kshitij,Cushman, Mark
, p. 6441 - 6444 (1994)
An unusual oxidative cyclization of chalcones by thallium (III) trinitrate (TTN) to 4-methoxyaurones has been studied. A key feature of this reaction is the introduction of a methoxyl group into the aurone skeleton. Several reactions have been performed to understand the mechanism and regiochemistry of cyclization.
Synthesis and biological activities of some flavones
Sawant,Gill,Nirwan
, p. 61 - 66 (2013/12/04)
Chalcones are synthesized by a base catalyzed Claisen Schmidt condensation reaction and then treated with dimethylsulphoxide in presence of iodine to get flavones. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coilt P. aeruginosa, S. epidermidis and B. subtilis. All the flavones showed moderate to good activity. The structures of these compounds were confirmed by IR, UV, 1H NMR, Mass and elemental analysis.
Synthesis and anti-inflammatory effect of chalcones
Hsieh, Hsin-Kaw,Tsao, Lo-Ti,Wang, Jih-Pyang,Lin, Chun-Nan
, p. 163 - 171 (2007/10/03)
The process of degranulation of mast cells and neutrophils contributes to inflammatory disorders. Activation of microglial cells and macrophages is believed to be involved in inflammatory, infectious and degenerative diseases of the CNS. Combining the pot
A Novel Oxidative Cyclization of 2'-Hydroxychalcones to 4,5-Dialkoxyaurones by Thallium(III) Nitrate
Thakkar, Kshitij,Cushman, Mark
, p. 6499 - 6510 (2007/10/03)
Scope and mechanism studies are reported on a novel oxidative transformation of certain 2'-hydroxy-5'-methoxychalcones to aurones by thallium(II) nitrate (TTN) in alcoholic solvents.A key feature of the reaction is the incorporation of a solvent-derived alkoxy group at C-4 of the aurone.The thermodynamically more stable Z isomers of the aurones are obtained in all cases.Aurones are formed regardless of whether electron donating or electron attracting groups are present at the para position of the B ring of the starting chalcone.
