158532-72-0

Basic information

• Product Name: 2',3'-didehydro-2',3'-dideoxy-5-hydroxymethyluridine
• Synonyms: 2',3'-didehydro-2',3'-dideoxy-5-hydroxymethyluridine
• CAS NO: 158532-72-0
• Molecular Formula: C10H12N2O5
• Molecular Weight: 240.21268
• Mol File: 158532-72-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.485g/cm³
• PKA: 8.94±0.10(Predicted)
• CAS DataBase Reference: 2',3'-didehydro-2',3'-dideoxy-5-hydroxymethyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3'-didehydro-2',3'-dideoxy-5-hydroxymethyluridine(158532-72-0)
• EPA Substance Registry System: 2',3'-didehydro-2',3'-dideoxy-5-hydroxymethyluridine(158532-72-0)

Safety Data

• Hazardous Substances Data: 158532-72-0(Hazardous Substances Data)

Upstream product

• 210469-38-8 5'-O-acetyl-2',3'-didehydro-2',3'-dideoxy-5-acetoxymethyl-uridine 
• 917482-60-1 5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine 
• 917482-61-2 2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine 
• 917482-58-7 5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 
• 917482-62-3 5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine 
• 917482-59-8 5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate 
• 362-43-6 2',3'-O-isopropylideneuridine 
• 2073-43-0 2',3'-O,O-isopropylidene-5-methyluridine 
• 30414-00-7 5-(hydroxymethyl)uridine 
• 58-96-8 uridine 
• 3816-77-1 2',3'-O-isopropylidene-5-hydroxymethyl-uridine 
• 1463-10-1 5-Methyluridine 
• 512779-26-9 5'-O-tert-butyldiphenylsilyl-5-hydroxymethyl-2',3'-O-isopropylideneuridine 
• 210469-36-6 3',5'-di-O-acetyl-2'-bromo-2'-deoxy-5-acetoxymethyl-uridine 

Relevant articles and documents

Synthesis and antiviral activity of C-5 substituted analogues of d4T bearing methylamino- or methyldiamino-linker arms

A general strategy is reported for the preparation of C-5-methylamino- or methyldiamino-d4t analogues of 'different sizes'. Reactions of the 2',3'- didehydro-2',3'-dideoxy-C-5 hydroxymethyl precursor (7) with either polymethylene diamines (n = 6, 8, 10 and 12) or propargylamine proceed regioselectively via substitution reactions at the C-5 position of uracil. The compounds were evaluated for antiviral activity and cytotoxicity. No significant activity was observed for compounds 9, 11, and 13, but 10 and 12 exhibited a weak activity against HIV-1.