15855-48-8Relevant academic research and scientific papers
Bi(OTf)3-Catalyzed Multicomponent α-Amidoalkylation Reactions
Schneider, Angelika E.,Manolikakes, Georg
, p. 6193 - 6212 (2015)
A bismuth(III) triflate catalyzed three-component synthesis of α-substituted amides starting from amides, aldehydes, and (hetero)arenes is reported. The reaction has a broad substrate scope, encompassing formaldehyde as well as aryl and alkyl aldehydes. Low catalyst loadings are required, and water is formed as the only side product. The scope and limitation of this method will be discussed.
