158579-73-8

Basic information

• Product Name: 2-chloro-4-MethanesulfonaMidobenzoic acid
• Synonyms: 2-chloro-4-MethanesulfonaMidobenzoic acid;2-Chloro-4-(MethylsulfonaMido)benzoic Acid;2-chloro-4-(methylsulfonylamino)benzoic acid;2-chloro-4-[(methylsulfonyl)amino]benzoic acid
• CAS NO: 158579-73-8
• Molecular Formula: C8H8ClNO4S
• Molecular Weight: 249.67142
• Mol File: 158579-73-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 419.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.617±0.06 g/cm3(Predicted)
• PKA: 2.94±0.25(Predicted)
• CAS DataBase Reference: 2-chloro-4-MethanesulfonaMidobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-MethanesulfonaMidobenzoic acid(158579-73-8)
• EPA Substance Registry System: 2-chloro-4-MethanesulfonaMidobenzoic acid(158579-73-8)

Safety Data

• Hazardous Substances Data: 158579-73-8(Hazardous Substances Data)

Upstream product

• 46004-37-9 methyl 4-amino-2-chlorobenzoate 
• 158580-55-3 methyl 2-chloro-4(N-methylsulphonylamino)benzoate 
• 2457-76-3 4-amino-2-chlorobenzoic acid 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 716357-78-7 C₃₆H₄₁ClFN₅O₃S 

Relevant articles and documents

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

Potent and efficacious inhibitors of the hedgehog pathway for the treatment of cancer have been prepared using the 2-pyridyl biphenyl amide scaffold common to the clinical lead GDC-0449. Analogs with polar groups in the para-position of the aryl amide ring optimized potency, had minimal CYP inhibition, and possessed good exposure in rats. Compounds 9d and 14f potently inhibited hedgehog signaling as measured by Gli1 mRNA and were found to be equivalent or more potent than GDC-0449, respectively, when studied in a Ptch+/- medulloblastoma allograft model, that is, highly dependent on hedgehog signaling.

PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING

The invention provides novel inhibitors of hedgehog signaling that are useful as s therapeutic agent for treating malignancies where the compounds have the general formula (I): where A, X, Y R1, R2, R3, R4, m and n are as described herein.

Herbicidal 2-cyano-1,3-diones

Herbicides derived from 2-cyano-1,3-diones have the formula: STR1 wherein R, R1, R2 R3, R4 and R5 are as defined in the description. The compounds are intended for use pre- and post-emergence as selective herbicides in maize and a large number of other monocotyledon crops.