158580-55-3

Upstream product

• 46004-37-9 methyl 4-amino-2-chlorobenzoate 
• 124-63-0 methanesulfonyl chloride 
• 158579-73-8 2-chloro-4-(N-methylsulphonylamino)benzoic acid 
• 7664-93-9 sulfuric acid 

Downstream Products

• 1190947-28-4 methyl 2-chloro-4-(N-(2-methoxyethyl)methylsulfonamido)benzoate 
• 158579-73-8 2-chloro-4-(N-methylsulphonylamino)benzoic acid 
• 1190947-31-9 methyl 2-chloro-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoate 
• 1190947-30-8 methyl 2-chloro-4-(N-isobutylmethylsulfonamido)benzoate 
• 1190947-29-5 methyl 4-(N-(2-(1H-pyrrol-1-yl)ethyl)methylsulfonamido)-2-chlorobenzoate 

Relevant academic research and scientific papers

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

Potent and efficacious inhibitors of the hedgehog pathway for the treatment of cancer have been prepared using the 2-pyridyl biphenyl amide scaffold common to the clinical lead GDC-0449. Analogs with polar groups in the para-position of the aryl amide ring optimized potency, had minimal CYP inhibition, and possessed good exposure in rats. Compounds 9d and 14f potently inhibited hedgehog signaling as measured by Gli1 mRNA and were found to be equivalent or more potent than GDC-0449, respectively, when studied in a Ptch+/- medulloblastoma allograft model, that is, highly dependent on hedgehog signaling.

IMIDAZO [1,2A] PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION

The invention is directed to Compounds of Formula (I) as well as methods of making and using the compounds.

PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING

The invention provides novel inhibitors of hedgehog signaling that are useful as s therapeutic agent for treating malignancies where the compounds have the general formula (I): where A, X, Y R1, R2, R3, R4, m and n are as described herein.

Pyridyl inhibitors of hedgehog signalling

The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

Herbicidal 2-cyano-1,3-diones

Herbicides derived from 2-cyano-1,3-diones have the formula: STR1 wherein R, R1, R2 R3, R4 and R5 are as defined in the description. The compounds are intended for use pre- and post-emergence as selective herbicides in maize and a large number of other monocotyledon crops.