15861-75-3

Upstream product

• 6582-42-9 1-(3,4-dichlorophenyl)propan-1-one 
• 95-50-1 1,2-dichloro-benzene 

Downstream Products

• 29922-26-7 1-(3.4-Dichlor-phenyl)-2-(4-methoxy-benzylamino)-propanol-⁽¹⁾ 
• 15861-76-4 1-(3.4-Dichlor-phenyl)-2-amino-propanol-⁽¹⁾ 

Relevant academic research and scientific papers

Synthesis of Acyl Fluorides via DAST-Mediated Fluorinative C-C Bond Cleavage of Activated Ketones

A new protocol for preparation of acyl fluorides was developed by recognizing activated ketones as starting materials. The method provides a different scope compared with previously reported methods that employ carboxylic acids as substrates. A working hypothesis of pull-and-push-driven fluorinative C-C bond cleavage was successfully demonstrated by the simple addition of diethylaminosulfur trifluoride (DAST) derivatives to α-oximinoketones. The designed reaction system led to a highly efficient and chemoselective reaction. The wide availability of the ketones allowed for a range of synthetically useful aryloyl and aliphatic acyl fluorides including those containing chiral skeletons. The method is mild, fast, scalable, and potentially one-pot operative.