15863-38-4Relevant academic research and scientific papers
Mono- And Dinuclear α-Diimine Nickel(II) and Palladium(II) Complexes in C-S Cross-Coupling
Talukder, Md Muktadir,Miller, Justin T.,Cue, John Michael O.,Udamulle, Chinthaka M.,Bhadran, Abhi,Biewer, Michael C.,Stefan, Mihaela C.
, p. 83 - 94 (2021/01/14)
The usefulness of transition metal catalytic systems in C-S cross-coupling reactions is significantly reduced by air and moisture sensitivity, as well as harsh reaction conditions. Herein, we report four highly air- and moisture-stable well-defined mononuclear and bridged dinuclear α-diimine Ni(II) and Pd(II) complexes for C-S cross-coupling. Various ligand frameworks, including acenaphthene- and iminopyridine-based ligands, were employed, and the resulting steric properties of the catalysts were evaluated and correlated with reaction outcomes. Under aerobic conditions and low temperatures, both Ni and Pd systems exhibited broader substrate scope and functional group tolerance than previously reported catalysts. Over 40 compounds were synthesized from thiols containing alkyl, benzyl, and heteroaryl groups. Also, pharmaceutically active heteroaryl moieties are incorporated from thiol and halide sources. Notably, the bridged dinuclear five-coordinate Ni complex has outperformed the remaining three mono four- or six-coordinate complexes by giving almost quantitative yields across a broad substrate scope.
Development of a robust process for the preparation of high-quality dicyclopropylamine hydrochloride
Mudryk, Boguslaw,Zheng, Bin,Chen, Ke,Eastgate, Martin D.
, p. 520 - 527 (2014/05/06)
A short and efficient process for the preparation of high-quality dicyclopropylamine HCl salt is described. An oxygen-mediated Chan-Lam coupling of N-cyclopropyl 4-nitrobenzenesulfonamide with cyclopropylboronic acid was followed by an optimized p-nosyl deprotection with 1-decanethiol, providing the title compound in high chemical yield. This process addresses many of the challenges and liabilities inherent in previous synthetic approaches to this challenging molecule. The collection of key safety data enabled implementation of an oxygen-mediated process on-scale and ensured safe operation throughout development, optimization, and processing.
Synthesis and in vitro antifungal activity of 4-substituted phenylguanidinium salts
Braunerova, Gabriela,Buchta, Vladimir,Silva, Luis,Kunes, Jiri,Palat Jr., Karel
, p. 443 - 450 (2007/10/03)
A series of 4-substituted phenylguanidinium derivatives was synthesized and its antimicrobial activity was evaluated in vitro against eight potentially pathogenic strains of fungi.
Investigations on novel sulphur-containing "banana-shaped" liquid crystals
Heppke,Parghi,Sawade
, p. 745/311-752/318 (2007/10/03)
This paper details the investigations of a series of novel sulphur-containing "banana-shaped" liquid crystals, B-n(S) (n = 8-10). The materials exhibit a B3 phase and also a phase with a "spiral-domain" texture similar to that of the "B7/
