15863-40-8Relevant academic research and scientific papers
Monophosphine ligands promote Pd-catalyzed C-S cross-coupling reactions at room temperature with soluble bases
Xu, Jessica,Liu, Richard Y.,Yeung, Charles S.,Buchwald, Stephen L.
, p. 6461 - 6466 (2019)
The Pd-catalyzed cross-coupling of thiols with aromatic electrophiles is a reliable method for the synthesis of aryl thioethers, which are important compounds for pharmaceutical and agricultural applications. Since thiols and thiolates strongly bind late transition metals, previous research has focused on catalysts supported by chelating, bisphosphine ligands, which were considered less likely to be displaced during the course of the reaction. We show that, by using monophosphine ligands instead, more effective catalysis can be achieved. Notably, compared to previous methods, this increased reactivity allows for the use of much lower reaction temperature, soluble bases, and base-sensitive substrates. In contrast to conventional wisdom, our mechanistic data suggest that the extent of displacement of phosphine ligands by thiols is, first, not correlated with the ligand bulk or thiol nucleophilicity and, second, not predictive of the effectiveness of a given ligand in combination with palladium.
Synthesis and in vitro antifungal activity of 4-substituted phenylguanidinium salts
Braunerova, Gabriela,Buchta, Vladimir,Silva, Luis,Kunes, Jiri,Palat Jr., Karel
, p. 443 - 450 (2007/10/03)
A series of 4-substituted phenylguanidinium derivatives was synthesized and its antimicrobial activity was evaluated in vitro against eight potentially pathogenic strains of fungi.
Investigations on novel sulphur-containing "banana-shaped" liquid crystals
Heppke,Parghi,Sawade
, p. 745/311-752/318 (2007/10/03)
This paper details the investigations of a series of novel sulphur-containing "banana-shaped" liquid crystals, B-n(S) (n = 8-10). The materials exhibit a B3 phase and also a phase with a "spiral-domain" texture similar to that of the "B7/
