15863-52-2

Basic information

• Product Name: n-hexyl 4-nitrophenyl sulfone
• Synonyms: n-hexyl 4-nitrophenyl sulfone
• CAS NO: 15863-52-2
• Molecular Weight: 271.337
• Mol File: 15863-52-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: n-hexyl 4-nitrophenyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: n-hexyl 4-nitrophenyl sulfone(15863-52-2)
• EPA Substance Registry System: n-hexyl 4-nitrophenyl sulfone(15863-52-2)

Safety Data

• Hazardous Substances Data: 15863-52-2(Hazardous Substances Data)

Upstream product

• 15863-36-2 p-nitrophenyl n-hexyl thioether 
• 13113-79-6 sodium 4-nitrobenzenethiolate 
• 350-46-9 4-Fluoronitrobenzene 
• 111-31-9 Hexanethiol 

Downstream Products

• 23815-39-6 3,5-dimethoxy-1-(1-heptenyl)benzene 
• 80638-86-4 (Z)-(1-heptenyl)-4-nitrobenzene 
• 10201-59-9 (Z)-hept-1-en-1-ylbenzene 
• 10201-58-8 (E)-1-heptenylbenzene 
• 58435-18-0 (E)-1-(hept-1-enyl)-4-methoxybenzene 
• 58435-18-0 (Z)-1-(hept-1-en-1-yl)-4-methoxybenzene 
• 76287-59-7 1-bromo-4-(hept-1-en-1-yl)benzene 
• 149731-55-5 1-((E)-Hept-1-enyl)-2-nitro-benzene 

Relevant articles and documents

Synthesis of 4-nitrophenyl sulfones and application in the modified Julia olefination

4-Nitrophenyl (NP) sulfones have been successfully employed in the modified Julia olefination reaction with carbonyl compounds. The olefination reaction proceeds through a sequence of aldol addition, Smiles rearrangement, and elimination. The sulfones are easily prepared in high yields in a two-step sequence starting from inexpensive commercially available para- fluoronitrobenzenes via nucleophilic aromatic substitution by a mercaptane and subsequent oxidation under standard conditions. The modified Julia reaction between NP sulfones and a wide variety of aromatic aldehydes affords the corresponding styrenes, stilbenes and cinnamate derivatives in yields up to 97% and good stereoselectivities. A mechanistic rationale is advanced to explain the observed results. Georg Thieme Verlag Stuttgart.