1586824-01-2Relevant academic research and scientific papers
Synthesis of batracylin and its N-sulfonamido analogues in [b-3C-im][NTf2] ionic liquid
Tseng, Ming-Chung,Lai, Peng-Yeh,Shi, Lin,Li, Hsin-Yi,Tseng, Min-Jen,Chu, Yen-Ho
, p. 2629 - 2633 (2014/04/03)
Starting with commercial and inexpensive reagents, a high-yielding chemical process carried out in [b-3C-im][NTf2] ionic liquid was achieved to afford the synthesis of batracylin and its N-sulfonamido analogues. Among all compounds synthesized, compounds 1, 11, and 14 exhibit potent inhibitory activity against human topoisomerase 1 (hTop1).
