67199-66-0Relevant articles and documents
Synthesis of batracylin and its N-sulfonamido analogues in [b-3C-im][NTf2] ionic liquid
Tseng, Ming-Chung,Lai, Peng-Yeh,Shi, Lin,Li, Hsin-Yi,Tseng, Min-Jen,Chu, Yen-Ho
, p. 2629 - 2633 (2014/04/03)
Starting with commercial and inexpensive reagents, a high-yielding chemical process carried out in [b-3C-im][NTf2] ionic liquid was achieved to afford the synthesis of batracylin and its N-sulfonamido analogues. Among all compounds synthesized, compounds 1, 11, and 14 exhibit potent inhibitory activity against human topoisomerase 1 (hTop1).
Synthesis and cytotoxic activity of conjugates of muramyl and normuramyl dipeptides with batracylin derivatives
Dzierzbicka, Krystyna,Trzonkowski, Piotr,Sewerynek, Przemys?aw,My?liwski, Andrzej
, p. 978 - 986 (2007/10/03)
The synthesis of MDP (muramyl dipeptide) or nor-MDP (normuramyl dipeptide) conjugates modified at the peptide part with batracylin (BAT) or batracylin derivatives is described. Batracylin was synthesized by our modified method (Scheme 3). The synthesis of BAT via this modified route now appears to be feasible on a multigram scale. Preliminary screening data obtained at the National Cancer Institute (NCI, Bethesda, MD) have revealed that the conjugates did not expose any cytotoxic activity even at 10-4-10-8 M or μg/mL. During tests performed at Medical University of Gdansk, Poland, two analogues 11c and 11e reduced the proliferation of Ab melanoma cells in vitro compared with batracylin alone (Table 2, Figure 1).
A Comparison of the Reactions of Some Ethyl N-Arylcarbamates with Those of the Corresponding Acetanilides. II Amidomethylation with N-Hydroxymethylphthalimide
Rosevear, Judi,Wilshire, John F. K.
, p. 339 - 353 (2007/10/02)
The reactions of some ethyl N-arylcarbamates and of the corresponding acetanilides towards 1 equiv. of N-hydroxymethylphthalimide in concentrated sulfuric acid at 50 deg C have been compared with one another.In the case of certain para-substituted compoun
