158697-66-6 Usage
Uses
Used in Pharmaceutical Industry:
Risperidal iMpurity B is used as a quality control standard for the assessment of Risperidone's purity and stability. It helps in the development of analytical methods for the detection and quantification of impurities in the final drug product, ensuring the safety and efficacy of the medication.
Risperidal iMpurity B is also used as a research tool in the study of Risperidone's metabolism and pharmacokinetics. Understanding the role of Risperidal iMpurity B in the therapeutic effects and side effects of Risperidone can aid in the optimization of drug dosages and the development of safer and more effective anti-psychotic medications.
Furthermore, Risperidal iMpurity B can be used in the development of personalized medicine strategies. Genetic variations in the CYP2D6 enzyme can affect the metabolism of Risperidone, leading to differences in the levels of Risperidal iMpurity B in individuals. By monitoring the levels of this impurity, healthcare professionals can tailor drug dosages to individual patients, minimizing side effects and maximizing therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 158697-66-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,6,9 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 158697-66:
(8*1)+(7*5)+(6*8)+(5*6)+(4*9)+(3*7)+(2*6)+(1*6)=196
196 % 10 = 6
So 158697-66-6 is a valid CAS Registry Number.
158697-66-6Relevant academic research and scientific papers
Process for making risperidone and intermediates therefor
-
Page/Page column 5, (2008/06/13)
The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.
A PROCESS FOR THE PREPARATION OF ANTIPSYCHOTIC RISPERIDONE
-
Page 5, (2008/06/13)
This invention relates to a process for the preparation of antipsychotic risperidone (Formula I); which comprises reacting 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido-[1,2-a]pyrimidin-4-one (Formula II); with 4-(2,4-difluorobenzoyl)piperidine oxime (Formula III); to form oxime (Formula IV); and in situ cyclization of oxime (Formula IV) to form risperidone (Formula I) in a solvent selected from the group consisting of acetonitrile, N,N-dimetylformamide and methyl isobutyl ketone.
